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Research projects in the Ghiladi group focus on the multiple roles of metal ions in biology and medicine, with the goals of elucidating enzyme pathways pertinent to disease states, understanding fundamental mechanisms of metalloenzymes involved in biocatalysis, investigating the limits of protein design and engineering, and the emergence of metallodrugs in pharmaceutical chemistry. We address each of these objectives using a highly interdisciplinary approach that is unique to the bioinorganic chemist. Namely, that enzymology, spectroscopy, molecular biology, synthetic inorganic chemistry, and protein biochemistry are all integral parts of the bigger picture of how metals interact with their environment in biological systems.

Recent News

August 2015: Congratulations to Leiah, who was just awarded a DOE Office of Science Graduate Student Research (SCGSR) Program Fellowship to study DHP using neutron diffraction at Oak Ridge National Lab!

July 2015: Congratulations to Nikolette for being awarded a departmental graduate fellowship for her work on uncovering the catalytic activities of DHP!

June 2015: Congratulations to Dr. Bradley Carpenter on his successful PhD defense! Brad is now off to Georgia Tech as a postdoctoral fellow in the lab of Prof. Wendy Kelly.

May 2015: Check out 3 new papers from Brad's PhD work on the publications page.

April 2015: Sarah wins a poster prize at NC State Spring Undergraduate Research Symposium, and is awarded a summer research fellowship from the Department of Chemistry.

March 2015: Sarah is awarded a travel grant from the Office of Undergraduate Research, and presents her work at the Spring ACS National Meeting in Denver.

Winter 2015: Congratulations to Roman Gavenko for his successful MS defense! Leiah and Nikolette present posters at the Gordon Research Seminar in Ventura, CA. Welcome to Yu Jeong Na from the Department of Fine Chemistry, Seoul National University of Science & Technology. Yu Jeong will be spending one year in the Ghiladi lab exploring non-native metals in DHP.

October 2014: Nikolette spends all of October at the University of Essex in Colchester, UK learning rapid-freeze-quench EPR from Dr. Dimitri Svistunenko. Sarah presents her work on antimicrobial materials at NC PhotoChem.

Fall 2014: Dr. Ghiladi is spending the Fall on sabbatical at the University of Essex.

August 2014: Congratulations to both Leiah and Nikolette for unconditional passing their doctoral candidacy exams!

July 2014: Leiah and Nikolette are presenting posters at BioMetals 2014 hosted at Duke University.

July 2014: Congratulations to Dr. David Barrios on his appointment as a postdoctoral fellow at Harvard Medical School.

June 2014: Drs. Ghiladi and Franzen presented talks at the 8th International Conference on Porphyrins and Phthalocyanines in Istanbul, Turkey.

April 2014: Check out David's paper on the new enzymatic functions of DHP in JACS!

March 2014: Great work from the Popescu lab - Mossbauer data on DHP presented by our collaborator at the ACS meeting in Dallas.

December 2013: Rania's EPR work is now online in the Journal of Biological Chemistry!

November 2013: Congratulations to Xingci Situ on the successful defense of her MS degree!

October 2013: Nikolette did a great job on her talk at SERMACS in Atlanta!

October 2013: Brad and Xingci present posters at NC PhotoChem at UNC Charlotte.

Spring '13: Congratulations to Dr. Ghiladi for winning the LeRoy and Elva Martin Award for Teaching Excellence!