Ghiladi Research Group

 

 

  1. Svistunenko, D. A.; Worrall, J.; Chugh, S.; Haigh, S.; Ghiladi, R. A.; Nicholls, P. “Ferric haem forms of Mycobacterium tuberculosis catalase-peroxidase probed by EPR spectroscopy: their stability and interplay with pH” Biochimie, 2012, in press.

  2. Carpenter, B.; Sadeghifar, H.; Argyropoulos, D.; Ghiladi, R. A. “Porphyrin-Cellulose Nanocrystals: A Photobactericidal Material that Exhibits Broad Spectrum Antimicrobial Activity” Photochem. Photobiol., 2012, in press.

  3. Ghiladi, R. A.; Rheingold, A. L.; Karlin, K. D. “Synthesis and Characterization of Trinuclear Copper Complexes as Models for the Catalytic Active Sites of Multicopper Enzymes” Inorg. Chim. Acta, 2012, in press.

  4. Franzen S.; Sasan, K.; Sturgeon, B. E.; Lyon, B. J.; Batternberg, B.; Gracz, H. S.; Dumarieh, R.; Ghiladi, R. A. “Non-Photochemical Base-Catalyzed Hydroxylation of 2,6-Dichloroquinone by H2O2 Occurs by a Radical Mechanism” J. Phys. Chem. B, 2012, 116, 1666-1676.

  5. Franzen, S.; Thompson, M. K.; Ghiladi, R. A. “The Dehaloperoxidase Paradox” BBA - Proteins and Proteomics, 2012, 1824, 578-588.

  6. D’Antonio, E. L., D’Antonio, J., de Serrano, V., Gracz, H., Thompson, M. K., Ghiladi, R. A., Bowden, E. F., and Franzen, S.; “Functional Consequences of the Creation of an Asp-His-Fe Triad in a 3/3 Globin.” Biochem., 2011, 50, 9664-9680.

  7. Feese, E.; Sadeghifar, H.; Gracz, H.; Argyropoulos, D.; Ghiladi, R. A.  "Photobactericidal Porphyrin-Cellulose Nanocrystals: Synthesis, Characterization and Antimicrobial Properties." Biomacromolecules, 2011, 12, 3528-3539.

  8. D’Antonio, J.; Ghiladi, R. A. “Reactivity of Deoxy- and Oxyferrous Dehaloperoxidase B from Amphitrite ornata: Identification of Compound II and its Ferrous-Hydroperoxide Precursor.” Biochem. 2011, 50, 5999-6011.

  9. Thompson, M. K.; Franzen, S.; Ghiladi, R. A.; Reeder, B.; Svistunenko, D. “Compound ES of Dehaloperoxidase Decays via Two Alternative Pathways Depending on the Conformation of the Distal Histidine” J. Am. Chem. Soc., 2010, 132, 17501-17510.

  10. D’Antonio, J.; D’Antonio, E. L.; Thompson, M. K.; Bowden, E. F.; Franzen, S.; Smirnova, T.; Ghiladi, R. A.* “Spectroscopic and Mechanistic Investigations of Dehaloperoxidase B from Amphitrite ornata” Biochem. 2010, 49, 6600-6616.

  11. De Serrano, V.; D’Antonio, J.; Franzen, S.; Ghiladi, R. A. “Structure of Dehaloperoxidase B at 1.58 Å Resolution and Structural Characterization of the A/B Dimer from Amphitrite ornata” Acta Cryst. 2010, D66, 529-538.

  12. Cade, C. E.; Medzihradszky, K. F.; Salas-Castillo, S. P.; Ghiladi, R. A. “Isoniazid-Resistance Conferring Mutations in Mycobacterium tuberculosis KatG: Catalase, Peroxidase, and INH-NADH Adduct Formation Activities” Protein Sci, 2010, 19, 458-474.

  13. Feese, E. and Ghiladi, R. A. “Highly Efficient Photodynamic Inactivation of Mycobacterium smegmatis” J. Antimicrob. Chemother., 2009, 64, 782-785.

  14. Feducia, J.; Dumarieh, R.; Gilvey, L. B. G.; Smirnova, T.; Franzen, S.; Ghiladi, R. A. “Characterization of Dehaloperoxidase Compound ES and its Reactivity with Trihalophenols” Biochem., 2009, 48, 995-1005.

  15. Maiti, D.; Woertink, J. S.; Ghiladi, R. A.; Solomon, E. I.; Karlin, K. D.* “Molecular Oxygen and Sulfur Reactivity of a Cyclotriveratrylene Derived Trinuclear Copper(I) Complex” Inorg. Chem., 2009, 48, 8342-8356. 

  16. R. A. Ghiladi, E. Chufan, D. del Río, E. I. Solomon, C. Krebs, B. H. Huynh, H.-w. Huang, P. Moënne-Loccoz, S. Kaderli, M. Honecker, A. D. Zuberbühler, L. Marzilli, R. J. Cotter, and K. D. Karlin “Further Insights into the Spectroscopic Properties, Electronic Structure and Kinetics of Formation of the Heme-Peroxo-Copper Complex [(F8TPP)FeIII-(O22–)-CuII(TMPA)]+” Inorg. Chem., 2007, 46, 3889-3902.

  17. R. A. Ghiladi, K. F. Medzihradszky, and P. R. Ortiz de Montellano. “The Role of the Met-Tyr-Trp Crosslink in Mycobacterium tuberculosis Catalase-Peroxidase (KatG) as Revealed by KatG(M255I)” Biochem. 2005, 44, 15093-15105.

  1. R. A. Ghiladi, K. F. Medzihradszky, F. M. Rusnak, and P. R. Ortiz de Montellano. “Correlation Between Isoniazid Resistance and Superoxide Reactivity in Mycobacterium tuberculosis KatG” J. Am. Chem. Soc. 2005, 127, 13428-13442.

  1. R. A. Ghiladi, G. M. Knudsen, K. F. Medzihradszky, and P. R. Ortiz de Montellano. “The Met-Tyr-Trp cross-link in Mycobacterium tuberculosis Catalase-Peroxidase (KatG): Autocatalytic Formation and Effect on Enzyme Catalysis and Spectroscopic Properties” J. Biol. Chem., 2005, 280, 22651-63.

  1. 10.R. A. Ghiladi, H.-w. Huang, P. Moënne-Loccoz, J. Stasser, N. J. Blackburn, A. S. Woods, R. J. Cotter, C. D. Incarvito, A. L. Rheingold and K. D. Karlin. “Heme-copper/dioxygen Adduct Formation Relevant to Cytochrome c Oxidase: Spectroscopic Characterization of [(6L)FeIII-(O22-)-CuII]+” J. Biol. Inorg. Chem. 2005, 10, 63-77.

  1. R. A. Ghiladi, D. E. Cabelli, P. R. Ortiz de Montellano. “Superoxide Reactivity of KatG: Insights into Isoniazid Resistance Pathways in TB” J. Am. Chem. Soc. 2004, 126, 4722-4723.

  1. D. W. Thompson, R. M. Kretzer, E. L. Lebeau, D. V. Scaltrio, R. A. Ghiladi, K.-C. Lam, A. L. Rheingold, K. D. Karlin and G. J. Meyer. “Synthesis, Characterization, and Laser Flash Photolysis Reactivity of a Reduced Carbonmonoxy Heme Complex” Inorg. Chem. 2003, 42, 5211-5218.

  1. R. M. Kretzer, R. A. Ghiladi, E. L. Lebeau, H.-C. Liang, and K. D. Karlin. “Synthesis and Characterization of Reduced Heme and Heme/Copper Carbonmonoxy Species” Inorg. Chem. 2003, 42, 3016-3025.

  1. R. A. Ghiladi and K. D. Karlin. “Low-Temperature UV-Visible and NMR Spectroscopic Investigations of O2 Binding to (6L)FeII, a Ferrous Heme Bearing Covalently Tethered Axial Pyridine Ligands” Inorg. Chem. 2002, 41, 2400-2407.

  1. R. A. Ghiladi, R. M. Kretzer, I. Guzei, A. L. Rheingold, Y.-M. Neuhold, K. R. Hatwell, A. D. Zuberbühler, and K. D. Karlin. “(F8TPP)FeII/O2 Reactivity Studies {F8TPP = Tetrakis(2,6-difluorophenyl)porphyrinate(2-)}: Spectroscopic (UV-Visible and NMR) and Kinetic Study of Solvent-Dependent (Fe/O2 = 1:1 or 2:1) Reversible O2-Reduction and Ferryl Formation” Inorg. Chem. 2001, 40, 5754-5767.

  1. R. A. Ghiladi, K. R. Hatwell, K. D. Karlin, H.-w. Huang, P. Moënne-Loccoz, C. Krebs, B. H. Huynh, L. Marzilli, R. J. Cotter, S. Kaderli, and A. D. Zuberbühler. “Dioxygen Reactivity of Mononuclear Heme and Copper Components Yielding A High-Spin Heme-Peroxo-Cu Complex” J. Am. Chem. Soc. 2001, 123, 6183-6184.

  1. P. Moënne-Loccoz, O. M. H. Richter, H.-w. Huang, I. M. Wasser, R. A. Ghiladi, and K. D. Karlin. “Nitric Oxide Reductase from Paracoccus Denitrificans Contains an Oxo-Bridged Heme/Non-Heme Diiron Center” J. Am. Chem. Soc. 2000, 122, 9344-9345.

  1. R. A. Ghiladi, T. D. Ju, D.-H. Lee, P. Moënne-Loccoz, S. Kaderli, Y.-M. Neuhold, A. D. Zuberbühler, A. S. Woods, R. J. Cotter, and K. D. Karlin. “Formation and Characterization of a High-Spin Heme-Copper (Peroxo) Complex” J. Am. Chem. Soc. 1999, 121, 9885-9886.

  1. T. D. Ju, R. A. Ghiladi, D.-H. Lee, G. P. F. van Strijdonck, A. S. Woods, R. J. Cotter, V. G. Young Jr., and K. D. Karlin. “Dioxygen Reactivity of Fully Reduced [LFeII… CuI]+ Complexes Utilizing Tethered Tetraarylporphyrins: Active Site Models for Heme-Copper Oxidases” Inorg. Chem. 1999, 38, 2244-2245.

 

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