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OVERALL OBJECTIVE

 

My research program is focused on identifying and understanding genes affecting economically important traits in dairy cattle and swine. Our approach involves genetic and genomic methods as the primary tools for our studies.

 

ONGOING RESEARCH PROJECTS

 

 

COW
  • Detection of quantitative trait loci affecting economically important traits in dairy cows

 

  • Effects of copper on liver and intestine gene expression in beef and dairy cattle
turkey
  • Effects of incubator environment on poultry growth plate expression
PIG
  • Transcript profiling and sequencing of genes involved in osteoarthritis using an in vitro porcine injury model

 

  • Proteonomic studies of porcine cartilage

 

 

 

 

PUBLICATIONS

 

Hansen, S.L., Ashwell, M.S., Legleiter, L.R., Fry, R.S., Lloyd, K.E. and Spears, J.W. (2009) The addition of high manganese to a copper deficient diet further depresses copper status and growth of cattle British Journal of Nutrition 101: 1068-1078.

 

Ashwell, M.S., O’Nan, A.T., Gonda, M.G. and Mente, P.L. (2008) Gene expression profiling of chondrocytes from a porcine impact injury model. Osteoarthritis and Cartilage 16: 936-946.

 

Blowe, C.D., Boyette, K.E., Ashwell, M.S., Eisen, E.J., Robison, O.W. and Cassady, J.P. (2006) Characterization of a line of pigs previously selected for increased litter size for RBP4 and follistatin. Journal of Animal Breeding and Genetics 123: 389-395.

 

Comparative mapping of bovine chromosome 27 with human chromosome 8 near a dairy form QTL in cattle. Connor EE, Ashwell MS, Schnabel R, Williams JL. Cytogenetic Genome Research. Vol 112, no. 1-2, pp. 98-102. 2006.

 

Detection of quantitative trait loci influencing conformation traits and calving ease in Holstein-Friesian cattle. Ashwell MS, Heyen DW, Weller JI, Ron M, Sonstegard TS, Van Tassell CP, Lewin HA. Journal of Dairy Science. Vol. 88, no. 11, pp. 4111-4119. Nov 2005.

 

Fine-mapping milk production quanitative trait loci on BTA6: Analysis of the bovine osteopontin gene Schnabel RD, Kim J, Ashwell MS, Sonstegard TS, Van Tassell CP, Conner EE, Taylor JF. Proceedings of the National Academy of Science. Vol. 102, no. 19, pp. 6895-6901. May 2005.

 

Whole-genome scan to detect QTL for milk production, conformation, fertility, and functional traits in two US Holsetin families Schnabel RD, Sonstegard TS, Taylor JF, Ashwell MS. Animal Genetics. Vol. 36, pp. 408-416. May 2005.

 

Detection of quantitative trait loci affecting milk production, health, and reproductive traits in Holstein cattle. Ashwell MS, Heyen DW, Sonstegard TS, Van Tassell CP, Da Y, VanRaden PM, Ron M, Weller JI, Lewin HA. Journal of Dairy Science. Vol. 87, no. 2, pp. 468-475. Feb 2004.

 

An expanded comparative map of bovine chromosome 27 targeting dairy form QTL regions. Connor EE, Sonstegard TS, Ashwell MS, Bennett GL, Williams JL. Animal Genetics. Vol. 35, pp. 265-269. Feb 2004.

 

Physical and linkage mapping of mammary-derived expressed sequence tags in cattle. Connor, EE; Sonstegard, TS; Keele, JW; Bennett, GL; Williams, JL; Papworth, R; Van Tassell; Ashwell, MS. Genomics. Vol. 83, no. 1, pp. 148-152. Jan 2004.

 

Mapping Quanitative Trait Loci Affecting Conformation to Chromosome 27 in Two Holstein Grandsire Families Van Tassell CP, Sonstegard TS, Ashwell MS. Journal of Dairy Science. Vol. 87, pp.450-457. 2004.

 

Genetic diversity and background linkage disequilibrium in the North American Holstein cattle population. Vallejo RL, Li YL, Rogers GW, Ashwell MS. Journal of Dairy Science. Vol. 86, no. 12, pp. 4137-4147. Dec 2003.

 

Characterization and expression of the bovine growth hormone-releasing hormone (GHRH) receptor. Connor EE, Ashwell MS, Dahl GE. Domestic Animal Endocrinology. Vol. 22, no. 4, pp. 189-200. Jun 2002.

 

A radiation hybrid map of bovine chromosome 27. Ashwell, MS; Sonstegard, TS; Kata, S; Womack, JE Animal Genetics. Vol. 33, no.1, pp.75-76. Feb 2002.

Isolation, characterization and mapping of the bovine signal peptidase subunit 18 gene. Ashwell, MS; Ashwell, CM; Garrett, WM; Bennett, GL. Animal Genetics. Vol 32, no. 4, pp. 232-233. Aug 2001.

 

A genome scan to identify quantitative trait loci affecting economically important traits in a US Holstein population. Ashwell MS, Van Tassell CP, Sonstegard TS. Journal of Dairy Science. Vol. 84, no. 11, pp. 2535-2542. 2001.

 

Comparative map alignment of BTA27 and HSA4 and 8 to identify conserved segments of genome containing fat desposition QTL. Sonstegard, TS; Garrett, WM; Ashwell, MS; Bennett, GL; Kappes, SM; Van Tassell, CP. Mammalian Genome. Vol. 11, no. 8, pp. 682-688. Aug 2000.

 

Detection of putative loci affecting milk, health, and conformation traits in a US Holstein population using 105 microsatellite markers. Van Tassell CP, Ashwell MS, Sonstegard TS. Journal of Dairy Science. Vol. 83, no. 8, pp. 1865-1872. Aug 2000.

 

Detection of putative loci affecting milk, health, and type traits in a US Holstein population using 70 microsatellite markers in a genome scan. Ashwell MS, Van Tassell CP. Journal of Dairy Science. Vol. 82, no. 11, pp. 2497-2502. Nov 1999.

 

Mapping of the bovine growth hormone-releasing hormone receptor (GHRH-R) gene to chromosome 4 by linkage analysis using a novel PCR-RFLP. Connor EE, Ashwell MS, Kappes SM, Dahl GE. Journal of Animal Science. Vol. 77, no. 3, pp. 793-794. Mar 1999.

 

Detection of putative loci affecting milk production and composition, health, and type traits in a United States Holstein population. Ashwell MS, Da Y, Van Tassell CP, Vanraden PM, Miller RH, Rexroad CE Jr. Journal of Dairy Science. Vol. 81, no. 12, pp. 3309-3314. Dec 1998.

 

Detection of putative loci affecting conformational type traits in an elite population of United States Holsteins using microsatellite markers. Ashwell MS, Da Y, VanRaden PM, Rexroad CE Jr, Miller RH. Journal of Dairy Science. Vol. 81, no. 4, pp. 1120-1125. Apr 1998.

 

Detection of loci affecting milk production and health traits in an elite US Holstein population using microsatellite markers. Ashwell, MS; Rexroad, CE Jr; Miller, RH; VanRAden, PM; Da, Y Animal Genetics. Vol. 28, no. 3, pp. 216-222. Jun 1997.

 

The bovine butyrophilin gene maps to chromosome 23 Ashwell, MS; Ogg, SL; Mather, IH Animal Genetics. Vol. 27, no. 3, pp. 171-173. 1996.

Mapping economic trait loci for somatic cell score in Holstein cattle using microsatellite markers and selective genotyping. Ashwell, MS; Rexroad, CE Jr; Miller,

 

RH, VanRaden, PM Animal Genetics Vol. 27, no. 4, pp. 235-242. 1996.

Development of 124 sequence-tagged sites and cytogenic localization of 217 cosmids for human chromosome 10. Zheng CJ, Ma NS, Dorman TE, Wang MT,

 

Braunschweiger K, Soares L, Schuster MK, Rothschild CB, Bowden DW, Torrey D, et. al. Genomics. Vol. 22, no. 1, pp. 55-67. Jul 1994.

D10S681, a microsatellite polymorphism near the RET locus. Shcuster MK, Bowden DW. Human Molecular Genetics. Vol. 3, no. 4, pp. 677. Apr 1994.

 

Germline RET mutations in Men2A and FMTC and their detection by simple DNA diagnostic tests. Xue F, Yu H, Maurer LH, Memoli VA, Nutile-McMenemy N, Schuster MK, Bowden DW, mao J, Noll WW. Human Molecular Genetics. Vol. 3, no. 4, pp. 635-638. Apr 1994.

 

Characterization of radiaton/fusiion hybrids containing parts of human chromosome 10 and their use in mapping chromsome 10-specific probes. Rothschild CB, Noll WW, Gravius TC, Schuster MK, Nutile-McMenemy N, Jone C, Bowden DW. Genomics. Vol. 13, no. 1, pp. 25-34. May 1992.