Research Projects

Electrochemistry and Behavior

We are interested in how endogenous chemicals such as acetylcholine and hydrogen peroxide, or highly addictive and commonly abused chemicals such as nicotine, work to modulate the dopamine system in behaving animals. We use real-time chemical measurements to delineate how specific chemical fluctuations underlie or impair a behavioral response. We study:

  1. motivated behavior and decision-making, as it relates to drug abuse and addiction
  2. malfunction of dopaminergic projections in neurodegenerative disease states involving oxidative stress (such as Parkinson's disease)

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