Welcome to TAK1 signaling

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Protein kinase TAK1 is a member of mitogen-activated protein kinase kinase kinase (MAPKKK) and plays a major role in inflammatory signaling pathways.  TAK1 activates mitogen-activated kinase (MAPK) cascades and IκB kinase-NF-κB pathways, but also modulates other molecules.      


We are characterizing tissue-specific TAK1-deficient mouse models, and have found that TAK1 signaling not only mediates inflammation but also modulates cell death and metabolism.  Our current research is focused on understanding the mechanisms of how TAK1 signaling regulates tissue homeostasis.  We also focus on identification of how TAK1 is activated in vivo

Members



Kazuhito Sai              Postdoctoral Research Associate



Former Members

Satoshi Kishida    Assistant Professor, Nagoya University Japan

Taisuke Kajino    Assistant Professor, Nagoya University Japan

Wei-Chun HuangFu    Assistant Professor, Taipei Medical University, Taiwan

Maiko Inagaki    Assistant Professor, Hiroshima University, Japan

Jae-Young Kim    Assistant Professor, Chungnam National University, South Korea

Rie Kajino-Sakamoto    Research Scientist, Aichi Cancer Center, Japan

Peter M. Broglie    Principal Scientist, BioAgilytix, NC

Emily Omori Takaki     Research Scientist, Otsuka Pharmaceutical, Japan

Giichi Takaesu    Associate Professor, Ryukyu University, Japan

Sho Morioka    Research Associate, University of Virginia, VA

September Mihaly   Regulatory writer

Alicia Simmons Postdoctoral Research Associate, NIEHS, NC

Yosuke Sakamachi Postdoctoral Research Associate, NIEHS, NC

Lab members

Publications

Photos

TAK1

TAB1

TAB2

Lab membersMembers.html
PublicationsPublications.html
PhotosPhotos.html
TAK1http://www.signaling-gateway.org/molecule/query?afcsid=A002249&type=molpage
TAB1http://www.signaling-gateway.org/molecule/query?afcsid=A002247&type=molpage
TAB2http://www.genecards.org/cgi-bin/carddisp.pl?gene=TAB2