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Research in the Horowitz laboratory focuses on the regulation of mammalian cell transcription and proliferation. Specifically, we are interested in understanding the functional and biochemical properties of the retinoblastoma (Rb) protein, the product of a tumor-suppressor gene, as well as targets and regulators of Rb function. In the last several years we have focused the majority of our attention on the structural and functional properties of Sp-family members and Nkx3.1, a homeodomain-containing transcription factor and tumor-suppressor gene. Most recently we have begun a series of studies focusing on regulatory mechanisms governing the subcellular localization of Sp-family members and Nkx3.1. These studies include the use of indirect immunofluorescence in fixed cells, and GFP-fusion proteins expressed in live cells that are monitored using time-lapse confocal microscopy.
For details regarding ongoing projects as well as a list of recent publications from the laboratory follow this handy link.
This page was last updated on 07/24/06. This web site was prepared with
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Horowitz Laboratory 
