|e-mail Dr. Lubischer [email@example.com]|
|An article describing my research can be found in Perspectives
I have traded my research program for more administrative responsibilities. But the research I conducted will always, to some extent, inform my teaching and my efforts in the development of courses and curricula within the field of neurobiology. So although I no longer accept students into the lab, I will leave posted this description of the work we did....
My research is driven by an interest in neural
development and plasticity throughout the life of the animal. The nervous system can alter its structure and function in response to a variety of
challenges or experiences. We study examples of this sort of plasticity using a model synapse in rats and mice.
|The photo above shows two neuromuscular junctions, labeled with 3 differently-colored fluorescent tags. In green are the axons and terminal endings of motoneurons. In red are acetylcholine receptors present in the muscle fiber membrane. In blue are the Schwann cells. Moving the cursor over the photo shows the Schwann cells by themselves.|
One area of research in the lab focuses on the plastic response of neuromuscular systems
to partial denervation of a muscle and the possible role of Schwann cells. In adulthood, mammalian motoneurons show excellent compensation for the
loss of neighboring motoneurons. After partial denervation of an adult muscle, the remaining motoneurons extend sprouts that reinnervate denervated
fibers. In contrast, after partial denervation of a muscle in early postnatal life, the remaining motoneurons fail to reinnervate denervated muscle
fibers. One objective of the research in my lab is to understand and explain these developmental differences in the neuronal response to injury.
Interestingly, Schwann cells also show a developmental change in response to nerve injury -- they extend processes after nerve injury in adult animals,
but undergo massive cell death after nerve injury in neonatal animals.
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|click here to read the abstracts of these articles|
Cahoy JD, Emery B, Kaushal A, Foo LC, Zamanian JL, Christopherson KS, Xing Y, Lubischer
JL, Krieg PA, Krupenko SA, Thompson WJ, Barres BA. (2008) A transcriptome database for astrocytes, neurons, and oligodendrocytes: A new resource
for understanding brain development and function. Journal
of Neuroscience 28(1):264-278.
Lubischer JL, Thompson WJ (1999) Neonatal partial denervation results in nodal, but not terminal, sprouting and a decrease in efficacy of remaining neuromuscular junctions in rat soleus muscle. Journal of Neuroscience 19(20):8931-8944.
Lubischer JL, Thompson WJ (1998) A neuregulin, glial growth factor (GGF2), reduces SNB motoneuron death during normal development. Society for Neuroscience Abstracts 24:1790.
Lubischer JL, Arnold AP (1995) Evidence for target regulation of the development of androgen sensitivity in rat spinal motoneurons. Developmental Neuroscience 17:106-117.
Lubischer JL, Arnold AP (1995) Axotomy of developing rat spinal motoneurons: cell survival, soma size, muscle recovery, and the influence of testosterone. Journal of Neurobiology 26:225-240.