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Postdoctoral Studies:

16. Silver(I)-Promoted Conversion of Thioamides to Amidines: Divergent Synthesis of a Key Series of Vancomycin Aglycon Residue 4 Amidines that Clarify Binding Behavior to Model Ligands. Okano, A.; James, R. C.; Pierce, J. G.; Xie, J.; Boger, D. L. J. Am. Chem. Soc. 2012, 134, 8790.

15. Redesign of Glycopeptide Antibiotics - Back to the Future. James, R. C.; Pierce, J. G.; Okano, A.; Xie, J.; Boger, D. L. ACS Chem Bio. 2012, 7, 000.

14. Total Synthesis of [Ψ[C(=S)NH]Tpg4] Vancomycin Aglycon, Ψ[C(=NH)NH]Tpg4] Vancomycin Aglycon, and Related Key Compounds: Reengineering Vancomycin for Dual D-Ala-D-Ala and D-Ala-D-Lac Binding. Xie, J.; Okano, A.; Pierce, J. G.; James, R. C.; Stamm, S.; Crane, C.; Boger, D. L. J. Am. Chem. Soc. 2012, 134, 1284.

13.  A Redesigned Vancomycin Engineered for Dual D-Ala-D-Ala and D-Ala-D-Lac Binding Exhibits Potent Antimicrobial Activity Against Vancomycin-Resistant Bacteria. Xie, J.; Pierce, J. G.; James, R. C.; Okano, A.; Boger, D. L. J. Am. Chem. Soc. 2011, 133, 13946.

Highlighted by: C&E News, Nature Chemical Biology, ACS Chemical Biology, Science Daily

12. Synthesis and Evaluation of Selected Key Methyl Ether Derivatives of Vancomycin Aglycon. Crane, C. M.; Pierce, J. G.; Leung, S. S. F.; Tirado-Rives, J.; Jorgensen, W. L.; Boger, D. L. J. Med. Chem. 2010, 53, 7229.

Undergraduate and Graduate Studies:

11. Synthesis of a library of tricyclic azepinoisoindolinones. Miller, B.; Mao, S.; Rosenker, K. M. G.; Pierce, J. G.; Wipf, P. Beilstein J. Org. Chem. 2012, 8, 1091.

10. Large-scale asymmetric synthesis of the bioprotective agent JP4-039 and analogs. Frantz, M-C.; Pierce, J. G.; Pierce, J. M.; Kangying, L.; Qingwei, W.; Johnson, M.; Wipf, P. Org. Lett. 2011, 13, 2318.

9. The Mitochondria-Targeted Nitroxide JP4-039 Augments Potentially Lethal Irradiation Damage Repair. Rajagopalan, M. S.; Gupta, K.; Epperly, M. W.; Franicola, D.; Zhang, X.; Wang, H.; Zhao, H.; Tyurin, V. A.; Pierce, J. G.; Kagan, V. E.; Wipf, P.; Kanai, A.; Greenberger, J. S. In Vivo 2009, 23, 717.

8. Synthesis of Hydroxylated L-Choi derivatives from L-Tyrosine: Octahydro-1H-indole Carboxylates. Wipf, P.; Pierce, J. G.; Fushimi, M.; Kasi, D.; Cuzzupe, A. J. Org. Chem. 2008, 73, 7807.

7. Synthesis of Functionalized Isoindolinones: Addition of In Situ Generated Organoalanes to Acyliminium Ions. Pierce, J. G.; Waller, D. L.; Wipf, P. J. Organometallic Chem. 2007, 692, 4618.

6. Expedient Synthesis of the α-C-Glycoside Analogue of the Immunostimulant Galactosylceramide (KRN7000). Wipf, P.; Pierce, J. G. Org. Lett. 2006, 8, 3375.

5. Synthesis of Homoallylic Amines by Hydrozirconation-Imine Addition of Allenes. Wipf, P.; Pierce, J. G. Org. Lett. 2005, 7, 3537.

4. Silver(I)-Catalyzed Addition of Zirconocenes to Glycal Epoxides. A New Synthesis of α-C-Glycosides. Wipf, P.; Pierce, J. G.; Zhuang, N. Org. Lett. 2005, 7, 483.

3. Lipase-Catalyzed Resolution of 4-Trimethylsilyl-3-Butyn-2-ol and Conversion of the (R)-Enantiomer to (R)-3-Butyn-2-yl-Mesulate and (P)-1-Tributylstannyl-1,2-Butadiene. Marshall, J. A.; Chobanian, H. Checked by Wipf, P.; Pierce, J. G. Org. Synth. 2005, 82, 43.

2. Catalytic Reduction of Amides to Amines with Hydrosilanes Using a Triruthenium Carbonyl Cluster as the Catalyst. Motoyama, Y.; Itonaga, C.; Ishida, T.; Takasaki, M.; Nagashima, H. Checked by Wipf, P.; Pierce, J. G. Org. Synth. 2005, 82, 188.

1. Investigation of Ligand Loading and Asymmetric Amplification in CHAOx-Catalyzed Diethylzinc Additions. Wipf, P.; Pierce, J. G.; Wang, X. Tetrahedron: Asymmetry (Special Issue on Asymmetric Syntheses on a Process Scale) 2003, 14, 3605.