The Pierce


est. 2012

Marine Natural Products Synthesis as a Platform for Chemical and Biological Discovery



The Pierce




Our Research Interests

Natural products and their analogs have provided the basis for countless biologically important drugs or probe molecules and continue to provide unique opportunities for synthetic chemistry, medicinal chemistry and chemical biology to explore.  We believe that innovative syntheses of newly discovered or historically significant natural products or natural product-like scaffolds will enable the development of novel biologically active agents for drug discovery and effective probes for biological study.  During the course of this work our constant aim is to push forward the efficiency, scalability and novelty of complex molecule synthesis and provide ample materials for a variety of evaluations both internally and through collaborations with experts in biology and related fields.





Joshua G Pierce

Research Team

Professor Joshua Pierce was born and raised in northwestern Pennsylvania and obtained a B.S. with Honors in Chemistry from the University of Pittsburgh.  Upon graduation he continued with graduate studies at Pitt under the direction of Professor Peter Wipf.  During these years his research was focused on organometallic methods development, natural product total synthesis and medicinal chemistry.


After defending his thesis in the fall of 2008, Joshua moved across the country to begin Postdoctoral studies with Professor Dale Boger at The Scripps Research Institute.  Research interests centered around complex natural product analogue synthesis, semi-synthesis and antimicrobial compound development.


Together these research experiences have provided an appreciation of the important role complex molecule synthesis plays in organic chemistry, medicinal chemistry and biology.  Professor Pierce’s research at NC State explores cutting edge problems in natural products synthesis and organic methods development with a constant goal of high impact contributions to chemistry, biology and materials science.

Postdoctoral Researchers:


         Yasamin Moazami


Graduate Students:


        Yunlong Shi

        Jonathan Mills

        Grant Edwards

        Patrick Parker

        Christina Martinez

        Nick Perry

        Kaylib Robinson

        Alain Valery

        Anna Cholewczynski

        Bram Frohock

        You-Chen Lin


Undergraduate Students:


        Alex Cusumano

        Yonghe Ge

        Naish Lalloo

        Jacob Nelson

        Peyton Williams


Curriculum Vitae

Looking for Talented Students and Postdocs!


Selected Publications Highlighted Below - For a Full Publication list, see CV

Synthesis of 1,4,2-Oxathiazoles via Oxidative Cyclization of Thiohydroximic Acids.  Lemercier, B. C.; Pierce, J. G. Org. Lett. 2015, 17, 4542.

Synthesis of the 5,6-Dihydroxymorpholin-3-one Fragment of Monanchocidin A. Shi, Y.; Pierce, J. G. Org. Lett. 2015, 17, 968.

A Rapid Synthesis of 4-Oxazolidinones: Total Synthesis of Synoxazolidinones A and B. Shymanska, N. V.; An, I. H.; Pierce, J. G. Angew. Chem. Int. Ed. 2014, 53, 5401.

Synthesis of Thiazolines by Copper Catalyzed Aminobromination of Thiohydroximic Acids. Lemercier, B. C.; Pierce, J. G. Org. Lett. 2014, 16, 2074.


Mailing Address:

Prof. Joshua Pierce

North Carolina State University

Department of Chemistry

Campus Box 8204

Raleigh, NC 27695-8204


Courier Shipping:

Prof. Joshua Pierce

NC State University, Dept. of Chemistry

2620 Yarbrough Drive, 45 Dabney Hall

Raleigh, NC 27695

Contact Info




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  3 @ 9 AM – Problem Session

  17 @ 9 AM – Current Literature - Group A

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 27 @ 9 AM - Molecule Challenge (select molecule 5/12)