Marine Natural Products Synthesis as a Platform for Chemical and Biological Discovery
Our Research Interests
Natural products and their analogs have provided the basis for countless biologically important drugs or probe molecules and continue to provide unique opportunities for synthetic chemistry, medicinal chemistry and chemical biology to explore. We believe that innovative syntheses of newly discovered or historically significant natural products or natural product-like scaffolds will enable the development of novel biologically active agents for drug discovery and effective probes for biological study. During the course of this work our constant aim is to push forward the efficiency, scalability and novelty of complex molecule synthesis and provide ample materials for a variety of evaluations both internally and through collaborations with experts in biology and related fields.
Looking for Talented Students and Postdocs!
Selected Publications Highlighted Below - For a Full Publication list, see CV
Synthesis of 1,4,2-Oxathiazoles via Oxidative Cyclization of Thiohydroximic Acids. Lemercier, B. C.; Pierce, J. G. Org. Lett. 2015, 17, 4542.
Synthesis of the 5,6-Dihydroxymorpholin-3-one Fragment of Monanchocidin A. Shi, Y.; Pierce, J. G. Org. Lett. 2015, 17, 968.
A Rapid Synthesis of 4-Oxazolidinones: Total Synthesis of Synoxazolidinones A and B. Shymanska, N. V.; An, I. H.; Pierce, J. G. Angew. Chem. Int. Ed. 2014, 53, 5401.
Synthesis of Thiazolines by Copper Catalyzed Aminobromination of Thiohydroximic Acids. Lemercier, B. C.; Pierce, J. G. Org. Lett. 2014, 16, 2074.
Prof. Joshua Pierce
North Carolina State University
Department of Chemistry
Campus Box 8204
Raleigh, NC 27695-8204
Prof. Joshua Pierce
NC State University, Dept. of Chemistry
2620 Yarbrough Drive, 45 Dabney Hall
Raleigh, NC 27695
PIERCE GROUP MEETINGS FALL 2016
18 @ 5 PM – Research Updates – All
3 @ 9 AM – Research Updates – All
9 @ 11 AM – Patrick Practice Talk (Prelim)
22 @ 5 PM – Mechanism Problem Session
1 @ 9 AM – Research Updates – All
6 @ 9 AM – Current Literature – Yunlong and Jonathan
11 @ 2 PM – Grant Practice Talk (Prelim)
22 @ 9 AM – Current Literature – Crissi and Patrick
5 @ 9 AM – Current Literature – Alain and Kaylib
8 @ 1 PM – Research Updates – All
19 @ 9 AM – Current Literature – Nick and Grant
10 @ 9 AM – Molecule Challenge
17 – Holiday Party - TBD