The Pierce

Group

est. 2012

Marine Natural Products Synthesis as a Platform for Chemical and Biological Discovery

 

 

The Pierce

Group

RESEARCH

RESEARCH & NEWS

Our Research Interests

Natural products and their analogs have provided the basis for countless biologically important drugs or probe molecules and continue to provide unique opportunities for synthetic chemistry, medicinal chemistry and chemical biology to explore.  We believe that innovative syntheses of newly discovered or historically significant natural products or natural product-like scaffolds will enable the development of novel biologically active agents for drug discovery and effective probes for biological study.  During the course of this work our constant aim is to push forward the efficiency, scalability and novelty of complex molecule synthesis and provide ample materials for a variety of evaluations both internally and through collaborations with experts in biology and related fields.

Funding

 

MEMBERS

Joshua G Pierce

Research Team

Professor Joshua Pierce was born and raised in northwestern Pennsylvania and obtained a B.S. with Honors in Chemistry from the University of Pittsburgh.  Upon graduation he continued with graduate studies at Pitt under the direction of Professor Peter Wipf.  During these years his research was focused on organometallic methods development, natural product total synthesis and medicinal chemistry.

 

After defending his thesis in the fall of 2008, Joshua moved across the country to begin Postdoctoral studies with Professor Dale Boger at The Scripps Research Institute.  Research interests centered around complex natural product analogue synthesis, semi-synthesis and antimicrobial compound development.

 

Together these research experiences have provided an appreciation of the important role complex molecule synthesis plays in organic chemistry, medicinal chemistry and biology.  Professor Pierce’s research at NC State explores cutting edge problems in natural products synthesis and organic methods development with a constant goal of high impact contributions to chemistry, biology and materials science.

Postdoctoral Researchers:

 

         Yasamin Moazami

 

Graduate Students:

 

        Yunlong Shi

        Jonathan Mills

        Grant Edwards

        Patrick Parker

        Christina Martinez

        Nick Perry

        Kaylib Robinson

        Alain Valery

 

Undergraduate Students:

 

        Alex Cusumano

        Naish Lalloo

        Jacob Nelson

        Peyton Williams

        Troy Zehnder

Curriculum Vitae

Looking for Talented Students and Postdocs!

PUBLICATIONS

Selected Publications Highlighted Below - For a Full Publication list, see CV

Synthesis of 1,4,2-Oxathiazoles via Oxidative Cyclization of Thiohydroximic Acids.  Lemercier, B. C.; Pierce, J. G. Org. Lett. 2015, 17, 4542.

Synthesis of the 5,6-Dihydroxymorpholin-3-one Fragment of Monanchocidin A. Shi, Y.; Pierce, J. G. Org. Lett. 2015, 17, 968.

A Rapid Synthesis of 4-Oxazolidinones: Total Synthesis of Synoxazolidinones A and B. Shymanska, N. V.; An, I. H.; Pierce, J. G. Angew. Chem. Int. Ed. 2014, 53, 5401.

Synthesis of Thiazolines by Copper Catalyzed Aminobromination of Thiohydroximic Acids. Lemercier, B. C.; Pierce, J. G. Org. Lett. 2014, 16, 2074.

MEETINGS & CONTACT

Mailing Address:

Prof. Joshua Pierce

North Carolina State University

Department of Chemistry

Campus Box 8204

Raleigh, NC 27695-8204

 

Courier Shipping:

Prof. Joshua Pierce

NC State University, Dept. of Chemistry

2620 Yarbrough Drive, 45 Dabney Hall

Raleigh, NC 27695

Contact Info

PIERCE GROUP MEETINGS FALL 2016

 

August

  18 @ 5 PM – Research Updates – All

 

September

  3 @ 9 AM – Research Updates – All

  9 @ 11 AM – Patrick Practice Talk (Prelim)

  22 @ 5 PM – Mechanism Problem Session

 

October

  1 @ 9 AM – Research Updates – All

  6 @ 9 AM – Current Literature – Yunlong and Jonathan

  11 @ 2 PM – Grant Practice Talk (Prelim)

  22 @ 9 AM – Current Literature – Crissi and Patrick

 

November

  5 @ 9 AM – Current Literature – Alain and Kaylib

  8 @ 1 PM – Research Updates – All

  19 @ 9 AM – Current Literature – Nick and Grant

 

December

  10 @ 9 AM – Molecule Challenge

  17 – Holiday Party - TBD