David S. Lalush
Department of Biomedical Engineering Office: 3142 Burlington Engineering
Laboratories |

- My interests in Biomedical Imaging:
- Tomographic reconstruction
*In vivo*anatomical and functional imaging of mice and rats

- Statistical reconstruction algorithms in single-photon emission computed tomography (SPECT) and positron emission tomography (PET)
- MicroCT reconstruction

- Statistical noise-reduction methods

- Converging-beam tomography
- Space- and time-domain image reconstruction and image processing
- Task-based image quality evaluation

- Micro CT system design and reconstruction
- Tomosynthesis system design and reconstruction

- MicroPET imaging of cardiac function

- MicroSPECT imaging of lung and brain function

- Bioinformatics Certificate, Stanford University
- Ph.D. Department of Biomedical Engineering, The University of North Carolina at Chapel Hill
- MSEE Department of Electrical and Computer Engineering, North Carolina State University
- BSEE Department of Electrical and Computer Engineering,
Lehigh University

1.
Lalush, D. S., “Binary encoding of
multiplexed images
in mixed noise,” *IEEE Transactions on
Medical Imaging*, vol. 27, pp. 1323-1332, 2008.

2.
Lalush, D. S., “CT, PET, and SPECT
Reconstruction
Algorithms,” in *Advances in Medical
Physics − 2008*. A. B. Wolbarst and W. R. Hendee (Eds.).

3. Pfeiler, T. W., D. S. Lalush, and E. G. Loboa, “Semiautomated Finite Element Mesh Generation Methods for a Long Bone,” Computer Methods and Programs in Biomedicine, vol. 85, pp. 196-202, 2007.

4.
Lalush,
D. S., M. K. Jatko, and W. P. Segars, “An observer study methodology
for
evaluating detection of motion abnormalities in gated myocardial
perfusion
SPECT,” *IEEE Transactions on Biomedical Engineering*, vol. 52,
pp.
480-485, 2005.

5.
Zhang, J., Y. Cheng, Y. Z. Lee, B. Gao, Q.
Qiu, W. L.
Lin, D. Lalush, J. P. Lu, and O. Zhou, “A nanotube-based field emission
X-ray
source for microcomputed tomography,” *Review
of Scientific Instruments*, vol. 76, 094301, 2005.

6.
Wang, W.-T., E. C. Frey, B. M. W. Tsui, D.
S. Lalush,
and C. Tocharoenchai, “Optimization of acquisition parameters for
simultaneous
201-Tl and 99m-Tc dual-isotope myocardial imaging,” *IEEE
Transactions on Nuclear Science*, vol. 52, pp. 1227-1235, 2005.

7.
Lalush, D. S., “Characterization, modeling,
and
simulation of mouse microarray images,” in *Methods of Microarray
Data
Analysis III*, (Eds, S. Lin and K. Johnson), Kluwer Academic
Publishers:

8.
Lalush, D. S. and M. A. Wernick, “Iterative
Reconstruction
Algorithms,” in *Emission Tomography: The Fundamentals of PET and
SPECT*,
(Eds. M. A. Wernick and J. N. Aarsvold), Academic Press:

9.
Lalush, D. S., and A. J. DiMeo, “A Monte Carlo investigation of dual-planar
circular-orbit cone-beam SPECT,” *Physics
in Medicine and Biology*, vol. 47, pp. 4357-4370, 2002.

10.
Lalush,
D. S., and A. J. DiMeo, “An observer study evaluating dual-planar
circular-orbit cone-beam brain SPECT,” *Journal
of Nuclear Medicine*, vol. 43, pp. 1578-1583, 2002.

11.
Segars,
W. P., D. S. Lalush, and B. M. W. Tsui, “Modeling respiratory mechanics
in the
MCAT and spline-based MCAT phantoms,” *IEEE
Transactions on Nuclear Science*, vol. 48, pp. 89-97, 2001.

12.
Lalush,
D. S. and B. M. W. Tsui, “Fast transmission CT reconstruction for SPECT
using a
block-iterative algorithm,” *IEEE
Transactions on Nuclear Science*, vol. 47, pp. 1123-1129, 2000.

13.
Lalush,
D. S., E. C. Frey, and B. M. W. Tsui, “Fast maximum entropy
approximation in
SPECT using the RBI-MAP algorithm,” *IEEE
Transactions on Medical Imaging*, vol. 19, pp. 286-294, 2000.

14.
Lalush,
D. S. and B. M. W. Tsui, “Performance of ordered subset reconstruction
algorithms under conditions of extreme attenuation and truncation in
cardiac
SPECT,” *Journal of Nuclear Medicine*,
vol. 41, pp. 737-744, 2000.

15.
Tsui,
B. M. W., W. P. Segars, and D. S. Lalush, “Effects of upward creep and
respiratory motion in myocardial SPECT,” *IEEE
Transactions on Nuclear Science*, vol. 47, pp. 1192-1195, 2000.

16.
Lalush,
D. S., “Fourier rebinning applied to multiplanar circular-orbit
cone-beam
SPECT,” *IEEE Transactions on Medical
Imaging*, vol. 18, pp. 1076-1084, 1999.

17.
Wollenweber,
S. D., B. M. W. Tsui, D. S. Lalush, E. C. Frey, K. J. LaCroix, and G.
T.
Gullberg, “Comparison of Hotelling observer models and human observers
in
defect detection from myocardial SPECT imaging,” *IEEE
Transactions on Nuclear Science*, vol. 46, pp. 2098-2103, 1999.

18.
Segars,
W. P., D. S. Lalush, and B. M. W. Tsui, “A realistic spline-based
dynamic heart
phantom,” *IEEE Transactions on Nuclear
Science*, vol. 46, pp. 503-506, 1999.

19.
Lalush,
D. S., and B. M. W. Tsui, “Mean-variance analysis of block-iterative
reconstruction algorithms modeling 3D detector response in SPECT,” *IEEE Transactions on Nuclear Science*,
vol. 45, pp.1280-1287, 1998.

20.
Lalush,
D. S., and B. M. W. Tsui, “Block-iterative techniques for fast 4D
reconstruction using *a priori* motion
models in gated cardiac SPECT,” *Physics
in Medicine and Biology*, vol. 43, pp. 875-886, 1998.

21.
Wollenweber,
S. D., D. S. Lalush, B. M. W. Tsui, and G. T. Gullberg, “Evaluation of
myocardial defect detection between parallel-hole and fan-beam SPECT
using the
Hotelling trace,” *IEEE Transactions on
Nuclear Science*, vol. 45, pp. 2205-2210, 1998.

22.
Tsui,
B. M. W., E. C. Frey, K. J. LaCroix, D. S. Lalush, W. H. McCartney, M.
A. King,
and G. T. Gullberg, “Quantitative myocardial perfusion SPECT,” *Journal of Nuclear Cardiology*, vol. 5,
pp. 507-522, 1998.

23.
Lalush,
D. S., and B. M. W. Tsui, “Space-Time Gibbs Priors Applied to Gated
SPECT
Myocardial Perfusion Studies,” *Three-Dimensional
Image Reconstruction in Radiology and Nuclear Medicine*, Kluwer
Academic
Publishers:

24.
Lalush,
D. S., and B. M. W. Tsui, “A fast and stable maximum *a
posteriori* conjugate gradient reconstruction
algorithm,”* Medical Physics*, vol. 22, pp.
1273-1284, 1995.

25.
DiBella,
E. V. R., R. L. Eisner, L. S. Schmarkey, A. B. Barclay, R. E.
Patterson, D.J.
Nowak, D. S. Lalush, and B. M. W. Tsui, “Heterogeneity of SPECT
bull’s-eyes in
normal dogs: comparison of attenuation compensation algorithms,” *IEEE Transactions on Nuclear Science*,
vol. 42, pp. 1290-1296, 1995.

26.
Lalush,
D. S., and B. M. W. Tsui, “Improving the convergence of iterative
filtered
backprojection algorithms,” *Medical
Physics*, vol. 21, pp. 1283-1286, 1994.

27.
Zhao,
X.D., B. M. W. Tsui, G. K. Gregoriou, D. S. Lalush, J. Li, and R. L.
Eisner,
“Evaluation of corrective reconstruction methods using a 3D
cardiac-torso
phantom and bull’s-eye plots*,” IEEE
Transactions on Nuclear Science*, vol. 41, pp. 2831-2837, 1994.

28.
Tsui,
B. M. W., E. C. Frey, X.-D. Zhao, D. S. Lalush, R. E. Johnston, and W.
H.
McCartney, “The importance and implementation of accurate
three-dimensional
compensation methods for quantitative SPECT,” *Physics in
Medicine and Biology*, vol. 39, pp. 509-530, 1994.

29.
Lalush,
D. S., and B. M. W. Tsui, “A generalized Gibbs prior for maximum *a posteriori *reconstruction in SPECT,” *Physics
in Medicine and Biology*, vol.
38, pp. 729-741, 1993.

30.
Lalush,
D. S., and B. M. W. Tsui, “Attenuation and detector response
compensations used
with Gibbs prior distributions for maximum *a
posteriori* reconstruction in SPECT,” *IEEE
Transactions on Nuclear Science*, vol. 39, pp. 1454-1459, 1992.

31.
Lalush,
D. S., and B. M. W. Tsui, “Simulation evaluation of Gibbs prior
distributions
for use in maximum *a posteriori* SPECT
reconstructions,” *IEEE Transactions on
Medical Imaging, *vol. 11, pp. 267-275, 1992.