David S. Lalush Associate Professor Biomedical Engineering Department of Biomedical Engineering North Carolina State University  Campus Box 7115 Raleigh, NC 27695-7115 Phone: 919.513.7671 FAX: 919.513.3814 Office: 3142 Burlington Engineering Laboratories  email: david_lalush@ ncsu.edu

Research Interests   Research Projects   Education   Refereed Journals and Books

Research Interests

• My interests in Biomedical Imaging:
• Tomographic reconstruction
• In vivo anatomical and functional imaging of mice and rats
  
• Statistical reconstruction algorithms in single-photon emission computed tomography (SPECT) and positron emission tomography (PET)
• MicroCT reconstruction
  
• Statistical noise-reduction methods
  
• Converging-beam tomography
• Space- and time-domain image reconstruction and image processing
• Task-based image quality evaluation
  

• Micro CT system design and reconstruction
• Tomosynthesis system design and reconstruction
  
• MicroPET imaging of cardiac function
  
• MicroSPECT imaging of lung and brain function
  

• Bioinformatics Certificate, Stanford University
• Ph.D. Department of Biomedical Engineering, The University of North Carolina at Chapel Hill
• MSEE Department of Electrical and Computer Engineering, North Carolina State University
• BSEE Department of Electrical and Computer Engineering, Lehigh University
  

1.      Lalush, D. S., “Binary encoding of multiplexed images in mixed noise,” IEEE Transactions on Medical Imaging, vol. 27, pp. 1323-1332, 2008.

2.      Lalush, D. S., “CT, PET, and SPECT Reconstruction Algorithms,” in Advances in Medical Physics − 2008. A. B. Wolbarst and W. R. Hendee (Eds.). Madison: Medical Physics Publishing, 2008.

3.      Pfeiler, T. W., D. S. Lalush, and E. G. Loboa, “Semiautomated Finite Element Mesh Generation Methods for a Long Bone,” Computer Methods and Programs in Biomedicine, vol. 85, pp. 196-202, 2007.

4.      Lalush, D. S., M. K. Jatko, and W. P. Segars, “An observer study methodology for evaluating detection of motion abnormalities in gated myocardial perfusion SPECT,” IEEE Transactions on Biomedical Engineering, vol. 52, pp. 480-485, 2005.

5.      Zhang, J., Y. Cheng, Y. Z. Lee, B. Gao, Q. Qiu, W. L. Lin, D. Lalush, J. P. Lu, and O. Zhou, “A nanotube-based field emission X-ray source for microcomputed tomography,” Review of Scientific Instruments, vol. 76, 094301, 2005.

6.      Wang, W.-T., E. C. Frey, B. M. W. Tsui, D. S. Lalush, and C. Tocharoenchai, “Optimization of acquisition parameters for simultaneous 201-Tl and 99m-Tc dual-isotope myocardial imaging,” IEEE Transactions on Nuclear Science, vol. 52, pp. 1227-1235, 2005.

7.      Lalush, D. S., “Characterization, modeling, and simulation of mouse microarray images,” in Methods of Microarray Data Analysis III, (Eds, S. Lin and K. Johnson), Kluwer Academic Publishers: Boston, 2003.

8.      Lalush, D. S. and M. A. Wernick, “Iterative Reconstruction Algorithms,” in Emission Tomography: The Fundamentals of PET and SPECT, (Eds. M. A. Wernick and J. N. Aarsvold), Academic Press: San Diego, 2005.

9.      Lalush, D. S., and A. J. DiMeo, “A Monte Carlo investigation of dual-planar circular-orbit cone-beam SPECT,” Physics in Medicine and Biology, vol. 47, pp. 4357-4370, 2002.

10.  Lalush, D. S., and A. J. DiMeo, “An observer study evaluating dual-planar circular-orbit cone-beam brain SPECT,” Journal of Nuclear Medicine, vol. 43, pp. 1578-1583, 2002.

11.  Segars, W. P., D. S. Lalush, and B. M. W. Tsui, “Modeling respiratory mechanics in the MCAT and spline-based MCAT phantoms,” IEEE Transactions on Nuclear Science, vol. 48, pp. 89-97, 2001.

12.  Lalush, D. S. and B. M. W. Tsui, “Fast transmission CT reconstruction for SPECT using a block-iterative algorithm,” IEEE Transactions on Nuclear Science, vol. 47, pp. 1123-1129, 2000.

13.  Lalush, D. S., E. C. Frey, and B. M. W. Tsui, “Fast maximum entropy approximation in SPECT using the RBI-MAP algorithm,” IEEE Transactions on Medical Imaging, vol. 19, pp. 286-294, 2000.

14.  Lalush, D. S. and B. M. W. Tsui, “Performance of ordered subset reconstruction algorithms under conditions of extreme attenuation and truncation in cardiac SPECT,” Journal of Nuclear Medicine, vol. 41, pp. 737-744, 2000.

15.  Tsui, B. M. W., W. P. Segars, and D. S. Lalush, “Effects of upward creep and respiratory motion in myocardial SPECT,” IEEE Transactions on Nuclear Science, vol. 47, pp. 1192-1195, 2000.

16.  Lalush, D. S., “Fourier rebinning applied to multiplanar circular-orbit cone-beam SPECT,” IEEE Transactions on Medical Imaging, vol. 18, pp. 1076-1084, 1999.

17.  Wollenweber, S. D., B. M. W. Tsui, D. S. Lalush, E. C. Frey, K. J. LaCroix, and G. T. Gullberg, “Comparison of Hotelling observer models and human observers in defect detection from myocardial SPECT imaging,” IEEE Transactions on Nuclear Science, vol. 46, pp. 2098-2103, 1999.

18.  Segars, W. P., D. S. Lalush, and B. M. W. Tsui, “A realistic spline-based dynamic heart phantom,” IEEE Transactions on Nuclear Science, vol. 46, pp. 503-506, 1999.

19.  Lalush, D. S., and B. M. W. Tsui, “Mean-variance analysis of block-iterative reconstruction algorithms modeling 3D detector response in SPECT,” IEEE Transactions on Nuclear Science, vol. 45, pp.1280-1287, 1998.

20.  Lalush, D. S., and B. M. W. Tsui, “Block-iterative techniques for fast 4D reconstruction using a priori motion models in gated cardiac SPECT,” Physics in Medicine and Biology, vol. 43, pp. 875-886, 1998.

21.  Wollenweber, S. D., D. S. Lalush, B. M. W. Tsui, and G. T. Gullberg, “Evaluation of myocardial defect detection between parallel-hole and fan-beam SPECT using the Hotelling trace,” IEEE Transactions on Nuclear Science, vol. 45, pp. 2205-2210, 1998.

22.  Tsui, B. M. W., E. C. Frey, K. J. LaCroix, D. S. Lalush, W. H. McCartney, M. A. King, and G. T. Gullberg, “Quantitative myocardial perfusion SPECT,” Journal of Nuclear Cardiology, vol. 5, pp. 507-522, 1998.

23.  Lalush, D. S., and B. M. W. Tsui, “Space-Time Gibbs Priors Applied to Gated SPECT Myocardial Perfusion Studies,” Three-Dimensional Image Reconstruction in Radiology and Nuclear Medicine, Kluwer Academic Publishers: Dordrecht, Netherlands, pp. 209-223, 1996.

24.  Lalush, D. S., and B. M. W. Tsui, “A fast and stable maximum a posteriori conjugate gradient reconstruction algorithm,” Medical Physics, vol. 22, pp. 1273-1284, 1995.

25.  DiBella, E. V. R., R. L. Eisner, L. S. Schmarkey, A. B. Barclay, R. E. Patterson, D.J. Nowak, D. S. Lalush, and B. M. W. Tsui, “Heterogeneity of SPECT bull’s-eyes in normal dogs: comparison of attenuation compensation algorithms,” IEEE Transactions on Nuclear Science, vol. 42, pp. 1290-1296, 1995.

26.  Lalush, D. S., and B. M. W. Tsui, “Improving the convergence of iterative filtered backprojection algorithms,” Medical Physics, vol. 21, pp. 1283-1286, 1994.

27.  Zhao, X.D., B. M. W. Tsui, G. K. Gregoriou, D. S. Lalush, J. Li, and R. L. Eisner, “Evaluation of corrective reconstruction methods using a 3D cardiac-torso phantom and bull’s-eye plots,” IEEE Transactions on Nuclear Science, vol. 41, pp. 2831-2837, 1994.

28.  Tsui, B. M. W., E. C. Frey, X.-D. Zhao, D. S. Lalush, R. E. Johnston, and W. H. McCartney, “The importance and implementation of accurate three-dimensional compensation methods for quantitative SPECT,” Physics in Medicine and Biology, vol. 39, pp. 509-530, 1994.

29.  Lalush, D. S., and B. M. W. Tsui, “A generalized Gibbs prior for maximum a posteriori reconstruction in SPECT,” Physics in Medicine and Biology, vol. 38, pp. 729-741, 1993.

30.  Lalush, D. S., and B. M. W. Tsui, “Attenuation and detector response compensations used with Gibbs prior distributions for maximum a posteriori reconstruction in SPECT,” IEEE Transactions on Nuclear Science, vol. 39, pp. 1454-1459, 1992.

31.  Lalush, D. S., and B. M. W. Tsui, “Simulation evaluation of Gibbs prior distributions for use in maximum a posteriori SPECT reconstructions,” IEEE Transactions on Medical Imaging, vol. 11, pp. 267-275, 1992.