The completion of the Human Genome Project has suggested that there are about 30,000 genes. However, it is thought that as many as ten million different kinds of proteins are generated from these genes and are expressed at levels that differ by over ten trillion! This is the challenge of proteomics: the study of all the proteins expressed by a given genome at a point in time. This enables us to understand the biological basis of disease, discover new diagnostic and prognostic markers, and develop new clinical tests.
Dr. Muddiman has published over 200 research articles and reviews on the fundamentals and applications of biological mass spectrometry, has presented over 225 invited lectures and his group has presented over 275 papers at national and international meetings. He has served on over 50 NIH study sections on genomics, proteomics and innovative technologies. Dr. Muddiman is currently on the advisory board of the National Science Foundation FT-ICR Mass Spectrometry Laboratory, National High Magnetic Field Laboratory and the Editorial Boards of Mass Spectrometry Reviews, Molecular & Cellular Proteomics, Journal of Chromatography B, and Rapid Communications in Mass Spectrometry. Dr. Muddiman received the 1999 American Society for Mass Spectrometry Research Award, was the recipient of the 2004 Arthur F. Findeis Award, American Chemical Society, was Elected to the Board of Directors of the United States Human Proteome Organization in 2009, received the NCSU Alumni Association Outstanding Research Award in 2009, was Appointed Chair of the 2011 United States Human Proteome Organization Meeting held in Raleigh, North Carolina, was Elected to the Board of the American Society for Mass Spectrometry in 2013, was Elected Treasurer of the United States Human Proteome Organization in 2013, and in 2014, was Elected President-Elect of the United States Human Proteome Organization.
The ultimate goals of our work are to quantitatively define biology and understand the role of individuality across a wide range of diseases. Our program requires a significant level of interaction with clinicians, basic scientists including biologists and chemists, statisticians as well as maintaining a large interdisciplinary group of scientists within our group driving innovations including advanced separations, state-of-the-art mass spectrometry, and bioinformatics. Collectively, the collaborative environment at North Carolina State University in concert with strategic collaborations with the Mayo Clinic College of Medicine, GSK, the UNC Chapel Hill Eshelman School of Pharmacy, puts our program on the cutting edge of basic and applied proteomics, glycomics and mass spectrometry imaging research.
David C. Muddiman is currently a Distinguished Professor of Chemistry and Founder and Director of the W.M. Keck FT-ICR Mass Spectrometry Laboratory at North Carolina State University in Raleigh, NC. Prior to moving his research group to North Carolina State University, David was a Professor of Biochemistry and Molecular Biology and Founder and Director of the Mayo Proteomics Research Center at the Mayo Clinic College of Medicine in Rochester, MN. Prior to his appointment at the Mayo Clinic, David was an Associate Professor of Chemistry at Virginia Commonwealth University where he began his academic career as an assistant professor in 1997 with an adjunct appointment in the Department of Biochemistry and Molecular Biophysics where he was also a member of the Massey Cancer Center.
David was born in Long Beach, CA in 1967 but spent most of his formative years in a small town in Pennsylvania. David received his B.S. in chemistry from Gannon University (Erie, PA) in 1990 and his Ph.D. in Analytical Chemistry from the University of Pittsburgh in 1995 under the auspices of David M. Hercules. He then was a Department of Energy Postdoctoral Fellow at Pacific Northwest National Laboratory in the Environmental Molecular Sciences Laboratory working with Richard D. Smith from 1995-1997. Importantly, David had gained significant experience in the area of surface science during his graduate work with Professor Hercules and then electrospray ionization and Fourier transform ion cyclotron resonance mass spectrometry with Dr. Smith. This is highly relevant as David drew from these two distinct areas in his background to develop the novel MSI imaging source: MALDESI.
David has served on over 50 NIH study sections since 1999 including being a charter permanent member of the Enabling Bioanalytical Technologies (EBT) study section which commenced in 2005. He also carries out significant scientific review for the NSF, Genome Canada, and DOE. Moreover, he reviews for over 30 scientific journals including Science, PNAS, and JACS. He has been a guest editor for Analytical and Bioanalytical Chemistry, Mass Spectrometry Reviews, the Journal of the American Society for Mass Spectrometry and the International Journal of Mass Spectrometry. He currently serves on the Editorial Advisory Board of Mass Spectrometry Reviews, Molecular and Cellular Proteomics, Rapid Communications in Mass Spectrometry, and the Journal of Chromatography B. David is also an Associate Editor for the Encyclopedia of Analytical Chemistry. He also serves on the advisory board of the NIH Funded Complex Carbohydrate Research Center, University of Georgia, National Science Foundation FT-ICR Mass Spectrometry Laboratory, National High Magnetic Field Laboratory, Florida State University and the Yale/NIDA Neuroproteomics Center, Yale University. He is currently a member of the ASMS Board of Directors (elected) and is the Treasurer and member of Executive Board of US-HUPO (elected) and recently President-Elect of US HUPO (elected).
His group has presented over 450 invited lectures and presentations at national and international meetings including 17 plenary/keynote lectures. His group has published over 200 peer-reviewed papers and has received four US patents. He is the recipient of the 2010 Biemann Medal, American Society for Mass Spectrometry, 2009 NCSU Alumni Outstanding Research Award, the 2004 ACS Arthur F. Findeis Award, the 1999 American Society for Mass Spectrometry Research Award, and the 1990-91 Safford Award, University of Pittsburgh, for Excellence in Teaching.