Peer Reviewed Publications


44. Worthington, R.J., Bunders, C.A.,, Reed, C.S., and Melander, C. Small Molecule Suppression of Carbapenem Resistance in NDM-1 producing Klebsiella pneumoniae. ACS Medicinal Chemistry Letters, Accepted.

43. Lindsey, E.A., Worthington, R.J., and Melander, C. 2-Aiminopyrimidine as a Novel Scaffold for Biofilm Modulation. Organic and BIomolecular Chemistry, In Press.

42. Su, Z., Peng, L., and Melander, C. A Modular Approach to the Synthesis of 1,4,5-Substituted-2-Aminoimidazoles. Tetrahedron Letters, In Press

41. Budhathoki-Uprety, J., Peng, L., Melander, C., and Novak, B.M. Synthesis of Guanidinium Functionalized Polycarbodiimides and their Antibacterial Activities. Acs Macro, In revision

40. Bunders, C.A., Minvielle, M.J., Worthington, R.J., Ortiz, M., Cavanagh, J., and Melander, C. Intercepting Bacterial Indole Signaling with Flustramine Derivatives. Journal of the American Chemical Society, In press.

39. Su, Z., Peng, L., Worthington, R.J., and Melander, C. Evaluation of 4,5-Disubstituted-2-Aminoimidazoles for Dual Antibiofilm/Antibiotic Resensitization Activity. ChemMedChem, 2011, 6, 2243-2251.

38. Stowe, S.D., Tucker, A.T, Rogers, S.A., Richards, J.J., Melander, C., and Cavanagh, J. Evaluation of 2-Aminomidizaole Toxicity in both Cellular and Model Organism Systems. Drug and Chemical Toxicology, In press.

37. Olson, A.L., Bobay, B.G., Melander, C, and Cavanagh, J. 1H, 13C, and 15N resonance assignments and secondary structure prediction of the full-length transition state regulator AbrB from Bacillus anthracis. Biomolecular NMR Assignments, In Press.

36. Harris, T., Worthington, R.J., and Melander, C. A Facile Synthesis of 1,5-Disubstituted-2-Aminoamidazoles: Antibiotic Activity of a First Generation Library. BIoorganic and Medicinal Chemistry Letters, 2011, 21 (15), 4516-4519.

35. Bunders, C.A., Cavanagh, J., and Melander, C. Flustramine Inspired Synthesis and Biological Evaluation of Pyrroloindoline Triazole Amides as Novel Inhibitors of Bacterial Biofilms. Organic and Biomolecular Chemistry, 2011, 9, 5476-5481.

34. Bresee, J., Maier, K.E., Boncella, A.E., Melander, C., and Feldheim, D.L. Growth Inhibition of Staphylococcus aureus by Mixed Monolayer Gold Nanoparticles. Small, 2011, 7 (14), 2027-2031.

33. Peng, L., DeSousa, J., Su., Z. Novak, B.M., Nevzorov, A.A., Garland, E., and Melander, C. Inhibition of Acinetobacter baumannii Biofilm Formation on a Methacrylate Polymer Containing a 2-Aminoimidazole Subunit. Chemical Communications, 2011, 47 (17), 4896-4898.

32. Liu, C., Worthington, R.J., Melander, C., and Wu, H. A New Small Molecule Specifically Inhibits the Cariogenic Bacterial Streptococcus mutans in Multispecies Biofilms. Antimicrobial Agents and Chemotherapy, 2011, 55 (6), 2679-2687.

31. Reyes, S., Huigens, R.W., Su, Z., Simon, M.L., and Melander, C. Synthesis and Biological Activity of 2-Aminoimidazole Triazoles Accessed by Suzuki-Miyaura Cross-Coupling. Organic and Biomolecular Chemistry, 2011, 9(8), 3041-3049.

30. Rogers, S.A., Lindsey, E.A, Whitehead, D.C., Mullikin, T. and Melander, C. The Evaluation of 2-Aminoimidazole/Carbamate Hybrid Motifs for Anti-Biofilm and Anti-Microbial Properties. Bioorganic and Medicinal Chemistry Letters, 2011, 21 (4), 1257-1260.

2010


29. Bresee, J., Maier, K.E., Melander, C., and Feldheim, D.L. Identification of Antibiotics Using Small Molecule Variable Ligand Display on Gold Nanopartilces, Chemical Communications, 2010, 46 (40), 7516-7518.

28. Reed, C.S., Huigens, R.W., Rogers, S.A., and Melander, C. Modulating the Development of E. coli Biofilms with 2-Aminoimidazoles. Bioorganic and Medicinal Chemistry Letters, 2010, 20 (21), 6310-6312.

27. Rogers, S.A., Whitehead, D.C., Mullikin, T., and Melander, C. Synthesis and Bacterial Biofilm Inhibition Studies of Ethyl N-(2-Phenethyl) Carbamate Derivatives. Organic and Biomolecular Chemistry, 2010, 8, 3857-3859.

26. Bunders, C., Richards, J.J., and Melander, C. Identification of Aryl 2-Aminoimidazoles as Biofilm Inhibitors of Gram-Negative Bacteria. Bioorganic and Medicinal Chemistry Letters, 2010, 20 (12), 3797-3800.

25. Su, Z., Rogers, S.A., McCall, W.S., Smith, A.C., Ravishankar, S., Mullikin, T., and Melander, C. A Nitroenolate Approach to the Synthesis of 4,5-Disubstituted-2-Aminoimidazoles. Pilot Library Assembly and Screening for Antibiotic and Antibiofilm Activity. Organic and Biomolecular Chemistry, 2010, 8(12), 2814-2822.

24. Rogers, S.A., Huigens, R.W., Cavanagh, J., and Melander, C. Synergistic Effects Between Conventional Antibiotics and 2-Aminoimidazole-Derived Antibiofilm Agents. Antimicrobial Agents and Chemotherapy, 2010, 54 (5), 2112-2118.

23. Heinecke, C.L. and Melander, C. Analysis of Kinamycin D Mediated DNA Cleavage. Tetrahedron Letters, 2010, 51 (11), 1455-1458.

22. Huigens, R.W., Reyes, S., Reed, C.S., Bunders, C., Rogers, S.A., Steinhauer, A.T., and Melander, C. The Chemical Synthesis and Antibiotic Activity of a Diverse Library of 2-Aminobenzimidazole Small Molecules Against MRSA and Multidrug-Resistant A. bamannii. Bioorganic and Medicinal Chemistry, 2010, 18 (2), 663-674.

21. Rogers, S.A., Bero, J.D., amd Melander, C. Chemical Synthesis and Biological Screening of 2-Aminoimidzole-Based Bacterial and Fungal Antibiofilm Agents. ChemBioChem, 2010, 11 (3), 396-410.

2009



20. Richards, J.J.; Reyes, S.; Stowe, S.D.; Tucker, A.T.; Ballard, T.E.; Cavanagh, J.; and Melander, C. Amide Isosteres of Oroidin: Assessment of Antibiofilm Activity and C. elegans Toxicity. Journal of Medicinal Chemistry, 2009, 52 (15), 4582-4585.

19. Rogers, S.A., Huigens, R.W., and Melander, C. A 2-Aminobenzimidazole that Inhibits and Disperses Gram-Positive Biofilms Through a Zinc-Dependent Mechanism." Journal of the American Chemical Society, 2009, 131 (29), 9868–9869.

18. Melander, C., Moeller, P.D.R., Ballard, T.E., Richards, J.J., Huigens, R.W., and Cavanagh, J. Evaluation of Dihydrooroidin as an Antifouling Additive in Marine Paint. International Biodeterioration & Biodegradation. 2009, 63, 529-532.

17. Ballard, T.E., Richards, J.J., Aquino, A., Reed, C.S. and Melander, C. Anti-biofilm Activity of a Diverse Oroidin Library Generated through Reductive Acylation. Journal of Organic Chemistry, 2009, 74 (4), 1755-1758.

16. Huigens, R.W., Rogers, S.A., Steinhauer, A.T., and Melander, C. Inhibition of Acinetobacter baumannii, Staphylococcus aureus, and Pseudomonas aeruginosa Biofilms with a Class of TAGE-Triazole Conjugates. Organic and Biomolecular Chemistry, 2009, 7 (4), 794-802.

15. Rogers, S.A., Krayer, M., Lindsey, J.S., and Melander, C. Tandem Dispersion and Killing of Bacteria from a Biofilm. Organic and Biomolecular Chemistry, 2009, 7 (3), 603-606.

2008


14. Ballard, T. E., Richards, J.J., Wolfe, A.L., and Melander, C. Synthesis and Anti-biofilm Activity of a Second Generation Reverse Amide Oroidin Library: An SAR Study. Chemistry a European Journal, 2008, 14 (34), 10745-10761.

13. Richards, J.J., Reed, C.S., and Melander, C “Effects of N-Pyrrole Substitution on the Anti-Biofilm Activities of Oroidin Derivatives Against Acinetobacter baumannii. Bioorganic and Medicinal Chemistry Letters, 2008, 18 (15), 4325-4327.

12. Richards, J.J. and Melander, C. “Synthesis of a 2-Aminoimidazole Library for Anti-Biofilm Screening Utilizing the Sonogashira Reaction” Journal of Organic Chemistry, 2008, 73 (13), 5191-5193.

11. Rogers, S.A. and Melander, C. Construction and Screening of a 2-Aminoimidazole Library Identifies a Small Molecule Capable of Inhibiting and Dispersing Bacterial Biofilms Across Order, Class, and Phylum. Angewandte Chemie, 2008, 47 (28), 5229-5231.

10. Bowman, M.C., Ballard, T.E., Ackerson, C.J., Feldheim, D.J., Margolis, D.M., and Melander, C. Inhibition of HIV Fusion with Multivalent Gold Nanoparticles. Journal of the American Chemical Society, 2008, 130 (22), 6896-6897

9. Ballard, T.E. and Melander, C. Kinamycin-Mediated Cleavage of DNA under Biomemetic Conditions. Tetrahedron Letters. 2008, 49, 3157-3161.

8. Richards, J.J., Ballard, T. E., Huigens, R.W., and Melander, C. Synthesis and Screening of an Oroidin Library Against Pseudomonas aeruginosa Biofilms. ChemBioChem 2008, 9 (8), 1267-1279.

7. Huigens, R.W., Ma, L., Gambino, C., Basso, A., Moeller, P.D.R., Cavanagh, J., Wozniak, D. J., and Melander, C. Control of Bacterial Biofilms with Marine Alkaloid Derivatives. Molecular BioSystems, 2008, 4 (6), 614-621.

6. Richards, J.J., Ballard, T.E., and Melander, C. Inhibition and Dispersion of Pseudomonas aeruginosa Biofilms with Reverse Amide 2-Aminoimidazole Oroidin Analogues. Organic and Biomolecular Chemistry, 2008, 6 (8), 1356-1363

5. Richards, J.J., Huigens, R.W., Ballard, T. E., Basso, A., Cavanagh, J., and Melander, C. Inhibition and Dispersion of Proteobacterial Biofilms. Chemical Communications, 2008, 14, 1698-1700.

4. Burns. V.A., Bobay, B.G., Basso, A. Cavanagh, J., and Melander, C. Targeting RNA with Cysteine-Constrained Peptides. Bioorganic & Medicinal Chemistry Letters, 2008, 18 (2), 565-567.

2007


3. Huigens, R.W.; Richards, J. J.; Parise, G.; Ballard, T.E.; Zeng, W.; Deora, R.; Melander, C. Inhibition of Pseudomonas aeruginosa Biofilm Formation with Bromoageliferin Analogues. Journal of the American Chemical Society 2007, 129, (22), 6966-6967.

2006


2. Zeng, W.; Ballard, T. E.; Tkachenko, A. G.; Burns, V. A.; Feldheim, D. L.; Melander, C. Mimicking the Biological Activity of Diazobenzo[b]fluorene Natural Products with Electronically Tuned Diazofluorene Analogs. Bioorganic and Medicinal Chemistry Letters, 2006, 16, (19), 5148-5151.

1. Zeng, W.; Ballard, T. E.; Melander, C. Tuning the Oxidation Properties of Vanadium (V) Through Ligand Stoichiometry. Tetrahedron Letters 2006, 47, (33), 5923-5926.

Review Articles

1. Richards, J.J. and Melander, C. Controlling Bacterial Biofilms. (invited review) ChemBioChem, 2009, 10 (14), 2287-2294.

2. Richards, J.J. and Melander, C. Small Molecule Approaches Toward the Non-Microbicidal Modulation of Bacterial Biofilm Growth and Maintenance. (invited review) Anti-Infective Agents in Medicinal Chemistry, 2009, 8, 295-314.

3. Stowe, S.D., Richards, J.J., Tucker, A.T., Thompson, R. Melander, C., and Cavanagh, J. Anti-Biofilm Compounds Derived from Marine Sponges. Marine Drugs, 2011, 9 (11), 2010-2035.