Peer Reviewed
Publications
44. Worthington, R.J., Bunders, C.A.,, Reed, C.S., and
Melander, C. Small Molecule Suppression of
Carbapenem Resistance in NDM-1 producing Klebsiella
pneumoniae. ACS Medicinal Chemistry Letters,
Accepted.
43. Lindsey, E.A., Worthington, R.J., and Melander, C.
2-Aiminopyrimidine as a Novel Scaffold for Biofilm
Modulation. Organic and BIomolecular Chemistry, In
Press.
42. Su, Z., Peng, L., and Melander, C. A Modular Approach
to the Synthesis of 1,4,5-Substituted-2-Aminoimidazoles.
Tetrahedron Letters, In Press
41. Budhathoki-Uprety, J., Peng, L., Melander, C., and
Novak, B.M. Synthesis of Guanidinium Functionalized
Polycarbodiimides and their Antibacterial Activities.
Acs Macro, In revision
40. Bunders, C.A., Minvielle, M.J., Worthington, R.J.,
Ortiz, M., Cavanagh, J., and Melander, C. Intercepting
Bacterial Indole Signaling with Flustramine Derivatives.
Journal of the American Chemical Society, In
press.
39. Su, Z., Peng, L., Worthington, R.J., and Melander, C.
Evaluation of 4,5-Disubstituted-2-Aminoimidazoles for Dual
Antibiofilm/Antibiotic Resensitization Activity.
ChemMedChem, 2011, 6,
2243-2251.
38. Stowe, S.D., Tucker, A.T, Rogers, S.A.,
Richards, J.J., Melander, C., and Cavanagh, J. Evaluation
of 2-Aminomidizaole Toxicity in both Cellular and Model
Organism Systems. Drug and Chemical Toxicology, In
press.
37.
Olson, A.L., Bobay, B.G., Melander, C, and Cavanagh, J. 1H,
13C, and 15N resonance assignments and secondary structure
prediction of the full-length transition state regulator
AbrB from Bacillus anthracis. Biomolecular NMR
Assignments, In Press.
36. Harris, T., Worthington, R.J., and
Melander, C. A Facile Synthesis of
1,5-Disubstituted-2-Aminoamidazoles: Antibiotic Activity of
a First Generation Library. BIoorganic and Medicinal
Chemistry Letters, 2011, 21
(15), 4516-4519.
35. Bunders, C.A., Cavanagh, J., and Melander,
C. Flustramine Inspired Synthesis and
Biological Evaluation of Pyrroloindoline Triazole Amides as
Novel Inhibitors of Bacterial Biofilms. Organic and
Biomolecular Chemistry, 2011,
9, 5476-5481.
34. Bresee, J., Maier, K.E., Boncella, A.E., Melander, C.,
and Feldheim, D.L. Growth Inhibition of Staphylococcus
aureus by Mixed Monolayer Gold Nanoparticles.
Small, 2011, 7 (14),
2027-2031.
33. Peng, L., DeSousa, J., Su., Z. Novak, B.M., Nevzorov,
A.A., Garland, E., and Melander, C. Inhibition of
Acinetobacter baumannii Biofilm Formation on a
Methacrylate Polymer Containing a 2-Aminoimidazole Subunit.
Chemical Communications, 2011,
47 (17), 4896-4898.
32. Liu, C., Worthington, R.J., Melander, C., and Wu, H. A
New Small Molecule Specifically Inhibits the Cariogenic
Bacterial Streptococcus mutans in Multispecies
Biofilms. Antimicrobial Agents and Chemotherapy,
2011, 55 (6), 2679-2687.
31. Reyes, S., Huigens, R.W., Su, Z., Simon, M.L., and
Melander, C. Synthesis and Biological Activity of
2-Aminoimidazole Triazoles Accessed by Suzuki-Miyaura
Cross-Coupling. Organic and Biomolecular
Chemistry, 2011, 9(8),
3041-3049.
30. Rogers, S.A., Lindsey, E.A, Whitehead, D.C., Mullikin,
T. and Melander, C. The Evaluation of
2-Aminoimidazole/Carbamate Hybrid Motifs for Anti-Biofilm
and Anti-Microbial Properties. Bioorganic and Medicinal
Chemistry Letters, 2011, 21
(4), 1257-1260.
2010
29. Bresee, J., Maier, K.E., Melander, C., and Feldheim,
D.L. Identification of Antibiotics Using Small Molecule
Variable Ligand Display on Gold Nanopartilces, Chemical
Communications, 2010, 46
(40), 7516-7518.
28. Reed, C.S., Huigens, R.W., Rogers, S.A., and Melander,
C. Modulating the Development of E. coli Biofilms
with 2-Aminoimidazoles. Bioorganic and Medicinal
Chemistry Letters, 2010, 20
(21), 6310-6312.
27. Rogers, S.A., Whitehead, D.C., Mullikin, T., and
Melander, C. Synthesis and Bacterial Biofilm Inhibition
Studies of Ethyl N-(2-Phenethyl) Carbamate Derivatives.
Organic and Biomolecular Chemistry,
2010, 8, 3857-3859.
26. Bunders, C., Richards, J.J., and Melander, C.
Identification of Aryl 2-Aminoimidazoles as Biofilm
Inhibitors of Gram-Negative Bacteria. Bioorganic and
Medicinal Chemistry Letters, 2010,
20 (12), 3797-3800.
25. Su, Z., Rogers, S.A., McCall, W.S., Smith, A.C.,
Ravishankar, S., Mullikin, T., and Melander, C. A
Nitroenolate Approach to the Synthesis of
4,5-Disubstituted-2-Aminoimidazoles. Pilot Library Assembly
and Screening for Antibiotic and Antibiofilm Activity.
Organic and Biomolecular Chemistry,
2010, 8(12), 2814-2822.
24. Rogers, S.A., Huigens, R.W., Cavanagh, J., and
Melander, C. Synergistic Effects Between Conventional
Antibiotics and 2-Aminoimidazole-Derived Antibiofilm
Agents. Antimicrobial Agents and Chemotherapy,
2010, 54 (5), 2112-2118.
23. Heinecke, C.L. and Melander, C. Analysis of Kinamycin D
Mediated DNA Cleavage. Tetrahedron Letters,
2010, 51 (11), 1455-1458.
22. Huigens, R.W., Reyes, S., Reed, C.S., Bunders, C.,
Rogers, S.A., Steinhauer, A.T., and Melander, C. The
Chemical Synthesis and Antibiotic Activity of a Diverse
Library of 2-Aminobenzimidazole Small Molecules Against
MRSA and Multidrug-Resistant A. bamannii.
Bioorganic and Medicinal Chemistry,
2010, 18 (2), 663-674.
21. Rogers, S.A., Bero, J.D., amd Melander, C. Chemical
Synthesis and Biological Screening of 2-Aminoimidzole-Based
Bacterial and Fungal Antibiofilm Agents.
ChemBioChem, 2010, 11
(3), 396-410.
2009
20. Richards, J.J.; Reyes, S.; Stowe, S.D.; Tucker, A.T.;
Ballard, T.E.; Cavanagh, J.; and Melander,
C. Amide Isosteres of Oroidin: Assessment
of Antibiofilm Activity and C. elegans Toxicity.
Journal of Medicinal Chemistry,
2009, 52 (15), 4582-4585.
19. Rogers, S.A., Huigens, R.W., and Melander,
C. A 2-Aminobenzimidazole that Inhibits
and Disperses Gram-Positive Biofilms Through a
Zinc-Dependent Mechanism." Journal of the American
Chemical Society, 2009, 131 (29),
9868–9869.
18. Melander, C.,
Moeller, P.D.R., Ballard, T.E., Richards, J.J., Huigens,
R.W., and Cavanagh, J. Evaluation of Dihydrooroidin as an
Antifouling Additive in Marine Paint. International
Biodeterioration & Biodegradation.
2009, 63,
529-532.
17. Ballard, T.E., Richards, J.J., Aquino, A., Reed, C.S.
and Melander, C. Anti-biofilm Activity of a Diverse Oroidin
Library Generated through Reductive Acylation. Journal
of Organic Chemistry, 2009,
74 (4), 1755-1758.
16. Huigens, R.W., Rogers, S.A., Steinhauer, A.T., and
Melander, C. Inhibition of
Acinetobacter baumannii, Staphylococcus
aureus, and Pseudomonas aeruginosa Biofilms
with a Class of TAGE-Triazole Conjugates. Organic and
Biomolecular Chemistry, 2009,
7 (4), 794-802.
15. Rogers, S.A., Krayer, M., Lindsey, J.S., and Melander,
C. Tandem Dispersion and Killing of
Bacteria from a Biofilm. Organic and Biomolecular
Chemistry, 2009, 7 (3),
603-606.
2008
14. Ballard, T. E., Richards, J.J., Wolfe, A.L., and
Melander, C. Synthesis and Anti-biofilm Activity of a
Second Generation Reverse Amide Oroidin Library: An SAR
Study. Chemistry a European Journal,
2008, 14 (34), 10745-10761.
13. Richards, J.J., Reed, C.S., and Melander, C “Effects of
N-Pyrrole Substitution on the Anti-Biofilm
Activities of Oroidin Derivatives Against Acinetobacter
baumannii. Bioorganic and Medicinal Chemistry
Letters, 2008, 18 (15),
4325-4327.
12. Richards, J.J. and Melander, C. “Synthesis of a
2-Aminoimidazole Library for Anti-Biofilm Screening
Utilizing the Sonogashira Reaction” Journal of Organic
Chemistry, 2008, 73 (13),
5191-5193.
11. Rogers, S.A. and Melander, C.
Construction and Screening of a 2-Aminoimidazole Library
Identifies a Small Molecule Capable of Inhibiting and
Dispersing Bacterial Biofilms Across Order, Class, and
Phylum. Angewandte Chemie, 2008,
47 (28), 5229-5231.
10. Bowman, M.C., Ballard, T.E., Ackerson, C.J., Feldheim,
D.J., Margolis, D.M., and Melander, C.
Inhibition of HIV Fusion with Multivalent Gold
Nanoparticles. Journal of the American Chemical
Society, 2008, 130 (22),
6896-6897
9. Ballard, T.E. and Melander, C. Kinamycin-Mediated
Cleavage of DNA under Biomemetic Conditions.
Tetrahedron Letters. 2008, 49,
3157-3161.
8. Richards, J.J., Ballard, T. E., Huigens, R.W., and
Melander, C. Synthesis
and Screening of an Oroidin Library Against Pseudomonas
aeruginosa Biofilms. ChemBioChem
2008, 9 (8), 1267-1279.
7. Huigens, R.W., Ma, L., Gambino, C., Basso, A., Moeller,
P.D.R., Cavanagh, J., Wozniak, D. J., and Melander,
C. Control of Bacterial Biofilms with
Marine Alkaloid Derivatives. Molecular BioSystems,
2008, 4 (6), 614-621.
6. Richards, J.J., Ballard, T.E., and Melander,
C. Inhibition and Dispersion of
Pseudomonas aeruginosa Biofilms with Reverse Amide
2-Aminoimidazole Oroidin Analogues. Organic and
Biomolecular Chemistry, 2008, 6 (8),
1356-1363
5. Richards, J.J., Huigens, R.W., Ballard, T. E., Basso,
A., Cavanagh, J., and Melander, C.
Inhibition and Dispersion of Proteobacterial Biofilms.
Chemical Communications, 2008,
14, 1698-1700.
4. Burns. V.A., Bobay, B.G., Basso, A. Cavanagh, J., and
Melander, C. Targeting RNA with Cysteine-Constrained
Peptides. Bioorganic & Medicinal Chemistry
Letters, 2008, 18 (2),
565-567.
2007
3. Huigens, R.W.; Richards, J. J.; Parise, G.; Ballard,
T.E.; Zeng, W.; Deora, R.; Melander, C. Inhibition of
Pseudomonas aeruginosa Biofilm Formation with
Bromoageliferin Analogues. Journal of the American
Chemical Society 2007, 129,
(22), 6966-6967.
2006
2. Zeng, W.; Ballard, T. E.; Tkachenko, A. G.; Burns, V.
A.; Feldheim, D. L.; Melander, C.
Mimicking the Biological Activity of
Diazobenzo[b]fluorene Natural Products with
Electronically Tuned Diazofluorene Analogs. Bioorganic
and Medicinal Chemistry Letters,
2006, 16, (19), 5148-5151.
1. Zeng, W.; Ballard, T. E.; Melander, C.
Tuning the Oxidation Properties of Vanadium (V) Through
Ligand Stoichiometry. Tetrahedron Letters
2006, 47, (33), 5923-5926.
Review Articles
1. Richards, J.J. and
Melander, C. Controlling Bacterial
Biofilms. (invited review) ChemBioChem,
2009, 10 (14), 2287-2294.
2. Richards, J.J. and Melander, C. Small
Molecule Approaches Toward the Non-Microbicidal Modulation
of Bacterial Biofilm Growth and Maintenance. (invited
review) Anti-Infective Agents in Medicinal
Chemistry, 2009, 8, 295-314.
3. Stowe, S.D., Richards, J.J., Tucker, A.T., Thompson, R.
Melander, C., and Cavanagh, J. Anti-Biofilm Compounds
Derived from Marine Sponges. Marine Drugs,
2011, 9 (11), 2010-2035.