91. Melander, R.J., Minvielle, M.J., and Melander, C. Controlling Bacterial Behavior with Indole-Containing Natural Products and Derivatives (invited review). Submitted.

90. Stowe, S.D., Thompson, R.J., Peng, L., Su, Z., Blackledge, M.S., Coe, W.H., Johannes, E., Lapham, V.K., Mackenzie, J., Melander, C., and Cavanagh, J. Membrane-Permeabilizing Activity of Reverse-Amide 2-Aminoimidazole Antibiofilm Agents Against Gram-Negative Pathogen, Acinetobacter baumannii. Submitted.

89. Ackart, D.F., Lindsey, E.A., Podell, B.K., Melander, R.J., Basaraba, R.J., and Melander, C. In vitro Reversal of Mycobacterium tuberculosis Drug Resistanceby 2-Aminoimidazole Based Small Molecules. FEMS Pathogens and Disease, accepted.

88. Ackart, D.F., Parks, Q.M., Kirk, N.M., Podell, B.K., Melander, C., Orme, I.M., Leid, J.G., Nick, J.A., and Basaraba, R.J. Expression of Antimicrobial Drug Tolerance by Attached Communities of Mycobacterium tuberculosis. FEMS Pathogens and Disease, accepted.

87. Worthington, R.J, Richards, J.J., and Melander, C. Non-Microbicidal Control of Bacterial Biofilms with Small Molecules. Anti-Infective Agents, 2014, 12 (1), 120-38.

86. Bresee, J., Bond, C.M., Worthington, R.J., Smith, C.A., Carter, C.J., Simpson, C.A., Wang, G., Hartman, J., Osbaugh, N.A., Melander, C., and Feldheim, D.L. Nanoscale Structure-Activity Relationships, Mode of Action, and Biocompatibility of Gold Nanoparticle Antibiotics. Journal of the American Chemical Society, 2014, 136 (14), 5295-5300.

85. Harris, T.L., Worthington, R.J., Hittle, L.E., Zurawski, D.V., Ernst, R.K., and Melander, C. Small Molecule Downregulation of PmrAB Reverses Lipid A Modification and Breaks Colistin Resistance. ACS Chemical Biology, 2014, 9 (1), 127-7.

84. Minvielle, M.J., Eguren, K., and Melander, C. Highly Active Modulators of Indole Signaling to Alter Pathogenic Behavior in Gram-Negative and Gram-Positive Bacteria. Chemistry: A European Journal, 2013, 19 (51), 17595-602.

83. Blackledge, M.S., Worthington, R.J., and Melander, C. Biologically-Inspired Strategies for Combating Bacterial Biofilms. Current Opinion in Pharmacology, 2013, 13 (5), 699-706.

82. Minvielle, M.J., Bunders, C.A., and Melander, C. Indole/triazole Conjugates are Selective Inhibitors and Inducers of Bacterial Biofilms. MedChemComm, 2013, 4 (6), 916-919.

81. Worthington, R.J. and Melander, C. Overcoming Resistance to β-Lactam Antibiotics (JOCSynopsis). Journal of Organic Chemistry, 2013, 78 (9), 4207-4213.

80. Blackledge, M.S. and Melander, C. Programmable DNA-binding Small Molecules. Bioorganic and Medicinal Chemistry, 2013, 21 (20), 6101-14.

78. Worthington, R.J., Blackledge, M.S., and Melander, C. Small Molecule Inhibition of Bacterial Two-Component Systems to Combat Antibiotic Resistance and Virulence. Future Medicinal Chemistry, 2013, 5 (11), 1265-1284.

78. Worthington, R.J. and Melander, C. Combination Approaches to Combat Multi-Drug Resistant Bacteria. Trends in Biotechnology, 2013, 31 (3), 177-184.

77. Furlani, R., Yeagley, A.A., and Melander, C. A Flexible Approach to 1,4-Disubstituted 2-Aminoimidazoles that Inhibit and Disperse Biofilms and Potetiate the Effects of β-Lactams against Multi-Drug Resistant Bacteria. European Journal of Medicinal Chemistry, 2013, 62, 59-70.

76. Yeagley, A.A., McCullough, K., and Melander, C. N-Substituted 2-Aminoimidazole Inhibitors of MRSA Biofilm Formation Accessed Through Direct 1,3-Bis(tert-butoxycarbonyl)guanidine Cyclization. Organic and Biomolecular Chemistry, 2013, 11 (1), 130-137.

75. Thompson, R.J., Bobay, B.G., Stowe, S.D., Peng, L. Su, Z., Actis, L.A., Melander, C., and Cavanagh, J. Identification of BfmR, a Response Regulator Involved in Biofilm Development, as a Target for a 2-Aminoimidazole-Based Anti-Biofilm Agent. Biochemistry, 2012, 51 (49), 9776-9778.

74. Harris, T.L., Worthington, R.J., and Melander, C. Potent Small Molecule Suppression of Oxacillin Resistance in MRSA. Angewandte Chemie, 2012, 51 (45), 11254-11257.

73. Lindsey, E.A., Brackett, C.M., Mullikin, T., Alcaraz, C., and Melander, C. The Discovery of N-1 Substituted 2-Aminobenzimidazoles as Zinc-Dependent S. aureus Biofilm Inhibitors. MedChemComm, 2012, 3 (11), 1462-1465.

72. Su, Z., Yeagley, A.A., Su, R., Peng, L., and Melander, C. Structural Studies on 4,5-Disubstituted-2-Aminoimidazole-Based Biofilm Modulators that Suppress Bacterial Resistance to β-Lactams. ChemMedChem, 2012, 7 (11), 2030-2039.

71. Melander, C and Margolis, D.M. Forcing an Enemy into the Open. Nature Chemistry, 2012, 4 (9), 692-693.

70. Olson, A.L., Thompson, R.J., Melander, C., and Cavanagh, J. Chemical Shift Assignments and Secondary Structure Prediction of the C-Terminal Domain of the Response Regulator BfmR from Acinetobacter baumannii. Journal of Biomolecular NMR, 2012, 6 (1), 95-8.

69. Worthington, R.J. and Melander, C. Deconvoluting Interspecies Bacterial Communication. Angewandte Chemie, 2012, 51 (26), 6314-6315.

68. Worthington, R.J., Richards, J.J., and Melander, C. Chemical Control of Bacterial Biofilms, Organic and Biomolecular Chemistry, 2012, 10 (37), 7457 - 7474.

67. Worthington, R.J., Rogers, S.A., Huigens, R.W., Melander, C., and Ritchie, D.F. Foliar Applied Small Molecule That Suppresses Biofilm Formation and Enhances Control of Copper-Resistant Xanthomonas euvesicatoria on Peppers. Plant Disease, 2012 96 (11), 1638-1644.

66. Worthington, R.J., Bunders, C.A., Reed, C.S., and Melander, C. Small Molecule Suppression of Carbapenem Resistance in NDM-1 Producing Klebsiella penumoniae. ACS Medicinal Chemistry Letters, 2012 3 (5), 357-361.

65. Lindsey, E.A., Worthington, R.J., Alcaraz, C., and Melander, C. 2-Aminopyrimidine as a Novel Scaffold for Biofilm Modulation. Organic and Biomolecular Chemistry, 2012, 10 (13), 2552-2561.

64. Su, Z., Peng, L., and Melander, C. A Modular Approach to the Synthesis of 1,4,5-Substituted-2-Aminoimidazoles. Tetrahedron Letters, 2012, 53 (10), 1204-1206.

63. Budhathoki-Uprety, J., Peng, L., Melander, C., and Novak, B.M. Synthesis of Guanidinium Functionalized Polycarbodiimides and their Antibacterial Activities. ACS Macro Letters, 2012 1 (3), 370-374.

62. Bunders, C.A., Minvielle, M.J., Worthington, R.J., Ortiz, M., Cavanagh, J., and Melander, C. Intercepting Bacterial Indole Signaling with Flustramine Derivatives. Journal of the American Chemical Society, 2011, 133 (50), 20160-20163.

61. Stowe, S.D., Richards, J.J., Tucker, A.T., Thompson, R., Melander, C, and Cavanagh, J. Anti-Biofilm Compounds Derived from Marine Sponges. Marine Drugs, 2011, 9 (11), 2010-2035.

60. Stowe, S.D., Tucker, A.T, Rogers, S.A., Richards, J.J., Melander, C., and Cavanagh, J. Evaluation of 2-Aminomidizaole Toxicity in both Cellular and Model Organism Systems. Drug and Chemical Toxicology, 201235 (3), 310-315.

59. Su, Z., Peng, L., Worthington, R.J., and Melander, C. Evaluation of 4,5-Disubstituted-2-Aminoimidazoles for Dual Antibiofilm/Antibiotic Resensitization Activity. ChemMedChem, 2011, 6, 2243-2251.

58.Olson, A.L., Bobay, B.G., Melander, C, and Cavanagh, J. 1H, 13C, and 15N resonance assignments and secondary structure prediction of the full-length transition state regulator AbrB from Bacillus anthracis. Biomolecular NMR Assignments, 20126(1), 95-98.

57. Harris, T., Worthington, R.J., and Melander, C. A Facile Synthesis of 1,5-Disubstituted-2-Aminoamidazoles: Antibiotic and Antibiofilm Activity of a First Generation Library. Bioorganic and Medicinal Chemistry Letters, 2011, 21 (15), 4516-4519.

56. Bunders, C.A., Cavanagh, J., and Melander, C. Flustramine Inspired Synthesis and Biological Evaluation of Pyrroloindoline Triazole Amides as Novel Inhibitors of Bacterial Biofilms. Organic and Biomolecular Chemistry, 2011, 9, 5476-5481.

55. Bresee, J., Maier, K.E., Boncella, A.E., Melander, C., and Feldheim, D.L. Growth Inhibition of Staphylococcus aureus by Mixed Monolayer Gold Nanoparticles. Small, 2011, 7 (14), 2027-2031.

54. Peng, L., DeSousa, J., Su, Z., Novak, B.M., Nevzorov, A.A., Garland, E.R., and Melander, C. Inhibition of Acinetobacter baumannii Biofilm Formation on a Methacrylate Polymer Containing a 2-Aminoimidazole Subunit. Chemical Communications, 2011, 47 (17), 4896-4898.

53. Liu, C., Worthington, R., Melander, C., and Wu, H. Identification of potent small-molecule inhibitors for cariogenic biofilms. Antimicrobial Agents and Chemotherapy, 2011, 55(6), 2679-2687.

52. Rogers, S.A., Lindsey, E.A, Whitehead, D.C., Mullikin, T. and Melander, C. The Evaluation of 2-Aminoimidazole/Carbamate Hybrid Motifs for Anti-Biofilm and Anti-Microbial Properties. Bioorganic and Medicinal Chemistry Letters, 2011, 21 (4), 1257-1260.

51. Reyes, S., Huigens, R.W., Su, Z., Simon, M.L., and Melander, C. Synthesis and Biological Activity of 2-Aminoimidazole Triazoles Accessed by Suzuki-Miyaura Cross-Coupling, Organic and Biomolecular Chemistry, 2011, 9(8), 3041-3049.

50. Bresee, J., Maier, K.E., Melander, C., and Feldheim, D.L. Identification of Antibiotics Using Small Molecule Variable Ligand Display on Gold Nanoparticles, Chemical Communications, 2010, 46 (40), 7516-7518.

49. Reed, C.S., Huigens, R.W., Rogers, S.A., and Melander, C. Modulating the Development of E. coli Biofilms with 2-Aminoimidazoles, Bioorganic and Medicinal Chemistry Letters, 2010, 20 (21), 6310-6312.

48. Rogers, S.A., Whitehead, D.C., Mullikin, T., and Melander, C. Synthesis and Bacterial Biofilm Inhibition Studies of Ethyl N-(2-Phenethyl) Carbamate Derivatives. Organic and Biomolecular Chemistry, 2010, 8, 3857-3859.

47. Bunders, C., Richards, J.J., and Melander, C. Identification of Aryl 2-Aminoimidazoles as Biofilm Inhibitors of Gram-Negative Bacteria. Bioorganic and Medicinal Chemistry Letters, 2010, 20 (12), 3797-3800.

46. Su, Z., Rogers, S.A., McCall, W.S., Smith, A.C., Ravishankar, S., Mullikin, T., and Melander, C. A Nitroenolate Approach to the Synthesis of 4,5-Disubstituted-2-Aminoimidazoles. Pilot Library Assembly and Screening for Antibiotic and Antibiofilm Activity. Organic and Biomolecular Chemistry, 2010, 8(12), 2814-2822.

45. Rogers, S.A., Huigens, R.W., Cavanagh, J., and Melander, C. Synergistic Effects Between Conventional Antibiotics and 2-Aminoimidazole-Derived Antibiofilm Agents. Antimicrobial Agents and Chemotherapy, 2010, 54(5), 2112-2118.

44. Heinecke, C.L. and Melander, C. Analysis of Kinamycin D Mediated DNA Cleavage. Tetrahedron Letters, 2010, 51 (11), 1455-1458.

43. Huigens, R.W., Reyes, S., Reed, C.S., Bunders, C., Rogers, S.A., Steinhauer, A.T., and Melander, C. The Chemical Synthesis and Antibiotic Activity of a Diverse Library of 2-Aminobenzimidazole Small Molecules Against MRSA and Multidrug-Resistant A. bamannii. Bioorganic and Medicinal Chemistry, 2010, 18 (2), 663-674.

42. Rogers, S.A., Bero, J.D., and Melander, C. Chemical Synthesis and Biological Screening of 2-Aminoimidzole-Based Bacterial and Fungal Antibiofilm Agents. ChemBioChem, 2010, 11 (3), 396-410.

41. Richards, J.J. and Melander, C. Small Molecule Approaches Toward the Non-Microbicidal Modulation of Bacterial Biofilm Growth and Maintenance. Anti-Infective Agents in Medicinal Chemistry, 2009, 8, 295-314.

40. Richards, J.J. and Melander, C. Controlling Bacterial Biofilms. ChemBioChem, 2009, 10 (14), 2287-2294.

39. Richards, J.J.; Reyes, S.; Stowe, S.D.; Tucker, A.T.; Ballard, T.E.; Cavanagh, J.; and Melander, C. Amide Isosteres of Oroidin: Assessment of Antibiofilm Activity and C. elegans Toxicity. Journal of Medicinal Chemistry, 2009, 52 (15), 4582-4585.

38. Rogers, S.A., Huigens, R.W., and Melander, C. A 2-Aminobenzimidazole that Inhibits and Disperses Gram-Positive Biofilms Through a Zinc-Dependent Mechanism." Journal of the American Chemical Society, 2009, 131 (29), 9868–9869.

37. Melander, C., Moeller, P.D.R., Ballard, T.E., Richards, J.J., Huigens, R.W., and Cavanagh, J. Evaluation of Dihydrooroidin as an Antifouling Additive in Marine Paint. International Biodeterioration & Biodegradation. 2009, 63, 529-532.

36. Ballard, T.E., Richards, J.J., Aquino, A., Reed, C.S. and Melander, C. Anti-biofilm Activity of a Diverse Oroidin Library Generated through Reductive Acylation. Journal of Organic Chemistry, 2009, 74 (4), 1755-1758.

35. Huigens, R.W., Rogers, S.A., Steinhauer, A.T., and Melander, C. Inhibition of Acinetobacter baumannii, Staphylococcus aureus, and Pseudomonas aeruginosa Biofilms with a Class of TAGE-Triazole Conjugates. Organic and Biomolecular Chemistry, 2009, 7 (4), 794-802.

34. Rogers, S.A., Krayer, M., Lindsey, J.S., and Melander, C. Tandem Dispersion and Killing of Bacteria from a Biofilm. Organic and Biomolecular Chemistry, 2009, 7 (3), 603-606.

33. Ballard, T. E., Richards, J.J., Wolfe, A.L., and Melander, C. Synthesis and Anti-biofilm Activity of a Second Generation Reverse Amide Oroidin Library: An SAR Study. Chemistry a European Journal, 2008, 14 (34), 10745-10761.

32. Richards, J.J., Reed, C.S., and Melander, C. “Effects of N-Pyrrole Substitution on the Anti-Biofilm Activities of Oroidin Derivatives Against Acinetobacter baumannii. Bioorganic and Medicinal Chemistry Letters, 2008, 18 (15), 4325-4327.

31. Richards, J.J. and Melander, C. “Synthesis of a 2-Aminoimidazole Library for Anti-Biofilm Screening Utilizing the Sonogashira Reaction” Journal of Organic Chemistry, 2008, 73 (13), 5191-5193.

30. Rogers, S.A. and Melander, C. Construction and Screening of a 2-Aminoimidazole Library Identifies a Small Molecule Capable of Inhibiting and Dispersing Bacterial Biofilms Across Order, Class, and Phylum. Angewandte Chemie, 2008, 47 (28), 5229-5231.

29. Bowman, M.C., Ballard, T.E., Ackerson, C.J., Feldheim, D.J., Margolis, D.M., and Melander, C. Inhibition of HIV Fusion with Multivalent Gold Nanoparticles. Journal of the American Chemical Society, 2008, 130 (22), 6896-6897.

28. Ballard, T.E. and Melander, C. Kinamycin-Mediated Cleavage of DNA under Biomemetic Conditions. Tetrahedron Letters. 2008, 49, 3157-3161.

27. Richards, J.J., Ballard, T. E., Huigens, R.W., and Melander, C. Synthesis and Screening of an Oroidin Library Against Pseudomonas aeruginosa Biofilms. ChemBioChem 2008, 9 (8), 1267-1279.

26. Huigens, R.W., Ma, L., Gambino, C., Basso, A., Moeller, P.D.R., Cavanagh, J., Wozniak, D. J., and Melander, C. Control of Bacterial Biofilms with Marine Alkaloid Derivatives. Molecular BioSystems, 2008, 4 (6), 614-621.

25. Richards, J.J., Ballard, T.E., and Melander, C. Inhibition and Dispersion of Pseudomonas aeruginosa Biofilms with Reverse Amide 2-Aminoimidazole Oroidin Analogues. Organic and Biomolecular Chemistry, 2008, 6 (8), 1356-1363

24. Richards, J.J., Huigens, R.W., Ballard, T. E., Basso, A., Cavanagh, J., and Melander, C. Inhibition and Dispersion of Proteobacterial Biofilms. Chemical Communications, 2008, 14, 1698-1700.

23. Burns. V.A., Bobay, B.G., Basso, A., Cavanagh, J., and Melander, C. Targeting RNA with Cysteine-Constrained Peptides. Bioorganic & Medicinal Chemistry Letters, 2008, 18 (2), 565-567.

22. Huigens, R.W., Richards, J. J., Parise, G.; Ballard, T.E., Zeng, W., Deora, R., Melander, C. Inhibition of Pseudomonas aeruginosa Biofilm Formation with Bromoageliferin Analogues. Journal of the American Chemical Society 2007, 129, (22), 6966-6967.

21. Zeng, W., Ballard, T. E., Tkachenko, A. G., Burns, V. A., Feldheim, D. L., Melander, C. Mimicking the Biological Activity of Diazobenzo[b]fluorene Natural Products with Electronically Tuned Diazofluorene Analogs. Bioorganic and Medicinal Chemistry Letters, 2006, 16, (19), 5148-5151.

20. Zeng, W., Ballard, T. E., Melander, C. Tuning the Oxidation Properties of Vanadium (V) Through Ligand Stoichiometry. Tetrahedron Letters 2006, 47, (33), 5923-5926.

19. Burnet, R., Melander, C., Puckett, J. W., Son, L. S., Wells, R. D., Dervan, P. B., and Gottesfeld, J. G. DNA sequence-specific polyamides alleviate transcriptional inhibition associated with long GAA.TTC repeats in Friedreich’s ataxia. Proceedings of the National Academy of Science 2006, 103 (91), 11497-11502.

18. Gearha, M. D., Dickinson, L., Ehley, J., Melander, C., Dervan, P. B., Wright, P. E., Gottesfeld, J. M. Inhibition of DNA Binding by Human Estrogen-Related Receptor 2 and Estrogen Receptor a with Minor Groove Binding Polyamides. Biochemistry 2005, 44 (11): 4196-4203.

17. Ylisastigui, L., Coull, J. J., Rucker, V. C., Melander, C., Bosch, R. J., Brodie, S. J., Corey, L., Sodora, D. L., Dervan, P. B., Margolis, D. M. Polyamides Reveal a Role for Repression in Latency within Resting T Cells of HIV-Infected Donors. Journal of Infectious Diseases 2004, 190, (8), 1429-1437.

16. Melander, C., Burnett, R., Gottesfeld, J. M. Regulation of Gene Expression with Pyrrole-Imidazole Polyamides. Journal of Biotechnology 2004, 112, (1-2), 195-220.

15. Dickinson, L. A., Burnett, R., Melander, C., Edelson, B. S., Arora, P. S., Dervan, P. B., Gottesfeld, J. M. Arresting Cancer Proliferation by Small-Molecule Gene Regulation. Chemistry & Biology 2004, 11, (11), 1583-1594.

14. Suto, R. K., Edayathumangalam, R. S., White, C., Melander, C., Gottesfeld, J. M., Dervan, P. B., Luger, K. Crystal Structures of Nucleosome Core Particles in Complex with Minor Groove DNA-Binding Ligands. Journal of Molecular Biology 2003, 326, (2), 371-380.

13. Rucker, V. C., Melander, C., Dervan, P. B. Influence of beta-Alanine on Hairpin Polyamide Orientation in the DNA Minor Groove. Helvetica Chimica Acta 2003, 86, (6), 1839-1851.

12. Rucker, V. C., Foister, S., Melander, C., Dervan, P. B. Sequence Specific Fluorescence Detection of Double Strand DNA. Journal of The American Chemical Society 2003, 125, (5), 1195-1202.

11. Dudouet, B., Burnett, R., Dickinson, L. A., Wood, M. R., Melander, C., Belitsky, J. M., Edelson, B., Wurtz, N., Briehn, C., Dervan, P. B., Gottesfeld, J. M. Accessibility of Nuclear Chromatin by DNA Binding Polyamides. Chemistry & Biology 2003, 10, (9), 859-867.

10. Gottesfeld, J. M., Belitsky, J. M., Melander, C., Dervan, P. B., Luger, K. Blocking Transcription Through a Nucleosome with Synthetic DNA Ligands. Journal of Molecular Biology 2002, 321, (2), 249-263.

9. Ehley, J. A., Melander, C., Herman, D., Baird, E. E., Ferguson, H. A., Goodrich, J. A., Dervan, P. B., Gottesfeld, J. M. Promoter Scanning for Transcription Inhibition with DNA-Binding Polyamides. Molecular and Cellular Biology 2002, 22, (6), 1723-1733.

8. Coull, J. J., He, G. C., Melander, C., Rucker, V. C., Dervan, P. B., Margolis, D. M. Targeted Derepression of the Human Immunodeficiency Virus Type 1 Long Terminal Repeat by Pyrrole-Imidazole Polyamides. Journal of Virology 2002, 76, (23), 12349-12354.

7. Gottesfeld, J. M., Melander, C., Suto, R., Raviol, H., Luger, K., Dervan, P. B. Sequence-Specific Recognition of DNA in the Nucleosome by Pyrrole-Imidazole Polyamides. Journal of Molecular Biology 2001, 309, (3), 615-629

6. Baliga, R., Baird, E. E., Herman, D. M., Melander, C., Dervan, P. B., Crothers, D. M. Kinetic Consequences of Covalent Linkage of DNA Binding Polyamides. Biochemistry 2001, 40, (1), 3-8.

5. Melander, C., Herman, D. M., Dervan, P. B. Discrimination of A/T Sequences in the Minor Groove of DNA within a Cyclic Polyamide Motif. Chemistry-A European Journal 2000, 6, (24), 4487-4497.

4. Melander, C., Horne, D. A. Mutarotation of Tetramethylglucose Catalyzed by Ribonucleosides. Tetrahedron Letters 1997, 38, (5), 713-716.

3. Melander, C., Horne, D. A. Kinetic Analysis of Ester Aminolysis Catalyzed by Nucleosides in a Nonpolar Medium. Evidence of Bifunctional Catalysis. Journal of Organic Chemistry 1997, 62, (26), 9295-9297.

2. Melander, C., Horne, D. A. Ester Aminolysis Catalyzed by Nucleosides in a Nonpolar Medium. Journal of Organic Chemistry 1996, 61, (23), 8344-8346.

1. Kurth, M. J., Randall, L. A. A., Chen, C. X., Melander, C., Miller, R. B., Mcalister, K., Reitz, G., Kang, R., Nakatsu, T., Green, C. Library-Based Lead Compound Discovery-Antioxidants by an Analogous Synthesis Deconvolutive Assay Strategy. Journal of Organic Chemistry 1994, 59, (20), 5862-5864.