Peer Reviewed
Publications
2013
53. Minvielle, M.J.,
Bunders, C.A., and Melander, C. Indole/Triazole Conjugates
are Selective Inhibitors and Inducers of Bacterial
Biofilms. MedChemComm, Accepted.
52. Olson, A.L., Thompson, R.J., Melander, C., and Cavnagh,
J. Chemical Shift Assignments and Secondary Structure
Prediction of the C-Terminal Domain of the Response
Regulator from Acinetobacter baumannii.
Journal of Biomolecular NMR, Accepted.
51. Furlani, R.E., Yeagley, A.A., and Melander, C. A
Flexible Approach to 1,4-Disubstituted 2-Aminoimidazoles
that Inhibit and Disperse Biofilms and Potentiate the
Effects of β-Lactams
against Multi-Drug Resistant Bacteria. European Journal
of Medicinal Chemistry, 2013,
62, 59-70.
50. Yeagley, A.A., Su, Z., McCullough, K.D, Worthington,
R.J., and Melander, C. N-Substituted 2-Aminoimidazole
Inhibitors of MRSA Biofilm Formation Accessed Through
Direct 1,3-Bis(tert-butoxycarbonyl)guanidine
Cyclization. Organic and Biomolecular Chemistry,
2013, 11 (1), 130-137.
2012
49. Thompson, R.J., Bobay, B.G., Stowe, S.D., Peng. L., Su,
Z., Actis, L.A., Melander, C., and Cavanagh, J.
Identification of BfmR, A Response Regulator Involved in
Biofilm Development, as a Target for a
2-Aminoimidazole-Based Anti-Biofilm Agent.
Biochemistry, 2012, 51
(49) 9776-9778.
48. Su, Z., Yeagley, A.A., Su, R., Peng, L., and
Melander, C. Structural Studies on
4,5-Disubstituted-2-Aminoimidazole-Based Biofilm Modulators
that Suppress Bacterial Resistance to β-Lactams.
ChemMedChem, 2012, 7
(11), 2030-2039.
47. Harris, T.L., Worthington, R.J., and Melander, C.
Potent Small Molecule Suppression of Oxacillin Resistance
in MRSA. Angewandte Chemie, 2012,
51 (45), 11254-11257.
46. Lindsey, E.A., Brackett,
C.M., Mullikin, T., Alcaraz, C., and Melander, C. The
Discovery of N-1 Substituted 2-Aminobenzimidazoles as
Zinc-Dependent S. aureus Biofilm Inhibitors.
MedChemComm, 2012 3
(11), 1462-1465.
45. Worthington, R.J., Rogers, S.A., Huigens, R.W.,
Melander, C., and Ritchie, D.F. Foliar Applied Small
Molecule That Suppresses Biofilm Formation and Enhances
Control of Copper-Resistant Xanthomonas
euvesicatoria on Peppers. Plant Disease,
2012 96 (11), 1638-1644.
44. Worthington, R.J., Bunders, C.A.,, Reed, C.S., and
Melander, C. Small Molecule Suppression of
Carbapenem Resistance in NDM-1 producing Klebsiella
pneumoniae. ACS Medicinal Chemistry Letters,
2012 3 (5), 357-361.
43. Lindsey, E.A., Worthington, R.J., Alcaraz, C. and
Melander, C. 2-Aiminopyrimidine as a Novel Scaffold for
Biofilm Modulation. Organic and BIomolecular
Chemistry, 2012, 10 (13),
2552-2561.
42. Su, Z., Peng, L., and Melander, C. A Modular Approach
to the Synthesis of 1,4,5-Substituted-2-Aminoimidazoles.
Tetrahedron Letters, 2012,
53 (10), 1204-1206.
41. Budhathoki-Uprety, J., Peng, L., Melander, C., and
Novak, B.M. Synthesis of Guanidinium Functionalized
Polycarbodiimides and their Antibacterial Activities.
ACS Macro, 2012 1 (3),
370-374.
40. Stowe, S.D., Tucker, A.T, Rogers, S.A., Richards, J.J.,
Melander, C., and Cavanagh, J. Evaluation of
2-Aminomidizaole Toxicity in both Cellular and Model
Organism Systems. Drug and Chemical Toxicology,
2012 35 (3), 310-315.
39. Olson, A.L., Bobay, B.G., Melander, C, and Cavanagh, J.
1H, 13C, and 15N resonance assignments and secondary
structure prediction of the full-length transition state
regulator AbrB from Bacillus anthracis.
Biomolecular NMR Assignments,
2012, 6 (1), 95-98.
2011
38. Bunders, C.A.,
Minvielle, M.J., Worthington, R.J., Ortiz, M., Cavanagh,
J., and Melander, C. Intercepting Bacterial Indole
Signaling with Flustramine Derivatives. Journal of the
American Chemical Society, 2011,
133 (50), 20160-20163.
37.
Su, Z., Peng, L., Worthington, R.J., and Melander, C.
Evaluation of 4,5-Disubstituted-2-Aminoimidazoles for Dual
Antibiofilm/Antibiotic Resensitization Activity.
ChemMedChem, 2011, 6,
2243-225.
36. Harris, T., Worthington, R.J., and
Melander, C. A Facile Synthesis of
1,5-Disubstituted-2-Aminoamidazoles: Antibiotic Activity of
a First Generation Library. BIoorganic and Medicinal
Chemistry Letters, 2011, 21
(15), 4516-4519.
35. Bunders, C.A., Cavanagh, J., and Melander,
C. Flustramine Inspired Synthesis and
Biological Evaluation of Pyrroloindoline Triazole Amides as
Novel Inhibitors of Bacterial Biofilms. Organic and
Biomolecular Chemistry, 2011,
9, 5476-5481.
34. Bresee, J., Maier, K.E., Boncella, A.E., Melander, C.,
and Feldheim, D.L. Growth Inhibition of Staphylococcus
aureus by Mixed Monolayer Gold Nanoparticles.
Small, 2011, 7 (14),
2027-2031.
33. Peng, L., DeSousa, J., Su., Z. Novak, B.M., Nevzorov,
A.A., Garland, E., and Melander, C. Inhibition of
Acinetobacter baumannii Biofilm Formation on a
Methacrylate Polymer Containing a 2-Aminoimidazole Subunit.
Chemical Communications, 2011,
47 (17), 4896-4898.
32. Liu, C., Worthington, R.J., Melander, C., and Wu, H. A
New Small Molecule Specifically Inhibits the Cariogenic
Bacterial Streptococcus mutans in Multispecies
Biofilms. Antimicrobial Agents and Chemotherapy,
2011, 55 (6), 2679-2687.
31. Reyes, S., Huigens, R.W., Su, Z., Simon, M.L., and
Melander, C. Synthesis and Biological Activity of
2-Aminoimidazole Triazoles Accessed by Suzuki-Miyaura
Cross-Coupling. Organic and Biomolecular
Chemistry, 2011, 9 (8),
3041-3049.
30. Rogers, S.A., Lindsey, E.A, Whitehead, D.C., Mullikin,
T. and Melander, C. The Evaluation of
2-Aminoimidazole/Carbamate Hybrid Motifs for Anti-Biofilm
and Anti-Microbial Properties. Bioorganic and Medicinal
Chemistry Letters, 2011, 21
(4), 1257-1260.
2010
29. Bresee, J., Maier, K.E., Melander, C., and Feldheim,
D.L. Identification of Antibiotics Using Small Molecule
Variable Ligand Display on Gold Nanopartilces, Chemical
Communications, 2010, 46
(40), 7516-7518.
28. Reed, C.S., Huigens, R.W., Rogers, S.A., and Melander,
C. Modulating the Development of E. coli Biofilms
with 2-Aminoimidazoles. Bioorganic and Medicinal
Chemistry Letters, 2010, 20
(21), 6310-6312.
27. Rogers, S.A., Whitehead, D.C., Mullikin, T., and
Melander, C. Synthesis and Bacterial Biofilm Inhibition
Studies of Ethyl N-(2-Phenethyl) Carbamate Derivatives.
Organic and Biomolecular Chemistry,
2010, 8, 3857-3859.
26. Bunders, C., Richards, J.J., and Melander, C.
Identification of Aryl 2-Aminoimidazoles as Biofilm
Inhibitors of Gram-Negative Bacteria. Bioorganic and
Medicinal Chemistry Letters, 2010,
20 (12), 3797-3800.
25. Su, Z., Rogers, S.A., McCall, W.S., Smith, A.C.,
Ravishankar, S., Mullikin, T., and Melander, C. A
Nitroenolate Approach to the Synthesis of
4,5-Disubstituted-2-Aminoimidazoles. Pilot Library Assembly
and Screening for Antibiotic and Antibiofilm Activity.
Organic and Biomolecular Chemistry,
2010, 8(12), 2814-2822.
24. Rogers, S.A., Huigens, R.W., Cavanagh, J., and
Melander, C. Synergistic Effects Between Conventional
Antibiotics and 2-Aminoimidazole-Derived Antibiofilm
Agents. Antimicrobial Agents and Chemotherapy,
2010, 54 (5), 2112-2118.
23. Heinecke, C.L. and Melander, C. Analysis of Kinamycin D
Mediated DNA Cleavage. Tetrahedron Letters,
2010, 51 (11), 1455-1458.
22. Huigens, R.W., Reyes, S., Reed, C.S., Bunders, C.,
Rogers, S.A., Steinhauer, A.T., and Melander, C. The
Chemical Synthesis and Antibiotic Activity of a Diverse
Library of 2-Aminobenzimidazole Small Molecules Against
MRSA and Multidrug-Resistant A. bamannii.
Bioorganic and Medicinal Chemistry,
2010, 18 (2), 663-674.
21. Rogers, S.A., Bero, J.D., amd Melander, C. Chemical
Synthesis and Biological Screening of 2-Aminoimidzole-Based
Bacterial and Fungal Antibiofilm Agents.
ChemBioChem, 2010, 11
(3), 396-410.
2009
20. Richards, J.J.; Reyes, S.; Stowe, S.D.; Tucker, A.T.;
Ballard, T.E.; Cavanagh, J.; and Melander,
C. Amide Isosteres of Oroidin: Assessment
of Antibiofilm Activity and C. elegans Toxicity.
Journal of Medicinal Chemistry,
2009, 52 (15), 4582-4585.
19. Rogers, S.A., Huigens, R.W., and Melander,
C. A 2-Aminobenzimidazole that Inhibits
and Disperses Gram-Positive Biofilms Through a
Zinc-Dependent Mechanism." Journal of the American
Chemical Society, 2009, 131 (29),
9868–9869.
18. Melander, C.,
Moeller, P.D.R., Ballard, T.E., Richards, J.J., Huigens,
R.W., and Cavanagh, J. Evaluation of Dihydrooroidin as an
Antifouling Additive in Marine Paint. International
Biodeterioration & Biodegradation.
2009, 63,
529-532.
17. Ballard, T.E., Richards, J.J., Aquino, A., Reed, C.S.
and Melander, C. Anti-biofilm Activity of a Diverse Oroidin
Library Generated through Reductive Acylation. Journal
of Organic Chemistry, 2009,
74 (4), 1755-1758.
16. Huigens, R.W., Rogers, S.A., Steinhauer, A.T., and
Melander, C. Inhibition of
Acinetobacter baumannii, Staphylococcus
aureus, and Pseudomonas aeruginosa Biofilms
with a Class of TAGE-Triazole Conjugates. Organic and
Biomolecular Chemistry, 2009,
7 (4), 794-802.
15. Rogers, S.A., Krayer, M., Lindsey, J.S., and Melander,
C. Tandem Dispersion and Killing of
Bacteria from a Biofilm. Organic and Biomolecular
Chemistry, 2009, 7 (3),
603-606.
2008
14. Ballard, T. E., Richards, J.J., Wolfe, A.L., and
Melander, C. Synthesis and Anti-biofilm Activity of a
Second Generation Reverse Amide Oroidin Library: An SAR
Study. Chemistry a European Journal,
2008, 14 (34), 10745-10761.
13. Richards, J.J., Reed, C.S., and Melander, C “Effects of
N-Pyrrole Substitution on the Anti-Biofilm
Activities of Oroidin Derivatives Against Acinetobacter
baumannii. Bioorganic and Medicinal Chemistry
Letters, 2008, 18 (15),
4325-4327.
12. Richards, J.J. and Melander, C. “Synthesis of a
2-Aminoimidazole Library for Anti-Biofilm Screening
Utilizing the Sonogashira Reaction” Journal of Organic
Chemistry, 2008, 73 (13),
5191-5193.
11. Rogers, S.A. and Melander, C.
Construction and Screening of a 2-Aminoimidazole Library
Identifies a Small Molecule Capable of Inhibiting and
Dispersing Bacterial Biofilms Across Order, Class, and
Phylum. Angewandte Chemie, 2008,
47 (28), 5229-5231.
10. Bowman, M.C., Ballard, T.E., Ackerson, C.J., Feldheim,
D.J., Margolis, D.M., and Melander, C.
Inhibition of HIV Fusion with Multivalent Gold
Nanoparticles. Journal of the American Chemical
Society, 2008, 130 (22),
6896-6897
9. Ballard, T.E. and Melander, C. Kinamycin-Mediated
Cleavage of DNA under Biomemetic Conditions.
Tetrahedron Letters. 2008, 49,
3157-3161.
8. Richards, J.J., Ballard, T. E., Huigens, R.W., and
Melander, C. Synthesis
and Screening of an Oroidin Library Against Pseudomonas
aeruginosa Biofilms. ChemBioChem
2008, 9 (8), 1267-1279.
7. Huigens, R.W., Ma, L., Gambino, C., Basso, A., Moeller,
P.D.R., Cavanagh, J., Wozniak, D. J., and Melander,
C. Control of Bacterial Biofilms with
Marine Alkaloid Derivatives. Molecular BioSystems,
2008, 4 (6), 614-621.
6. Richards, J.J., Ballard, T.E., and Melander,
C. Inhibition and Dispersion of
Pseudomonas aeruginosa Biofilms with Reverse Amide
2-Aminoimidazole Oroidin Analogues. Organic and
Biomolecular Chemistry, 2008,
6 (8), 1356-1363
5. Richards, J.J., Huigens, R.W., Ballard, T. E., Basso,
A., Cavanagh, J., and Melander, C.
Inhibition and Dispersion of Proteobacterial Biofilms.
Chemical Communications, 2008,
14, 1698-1700.
4. Burns. V.A., Bobay, B.G., Basso, A. Cavanagh, J., and
Melander, C. Targeting RNA with Cysteine-Constrained
Peptides. Bioorganic & Medicinal Chemistry
Letters, 2008, 18 (2),
565-567.
2007
3. Huigens, R.W., Richards, J. J., Parise, G., Ballard,
T.E., Zeng, W., Deora, R., Melander, C. Inhibition of
Pseudomonas aeruginosa Biofilm Formation with
Bromoageliferin Analogues. Journal of the American
Chemical Society 2007, 129,
(22), 6966-6967.
2006
2. Zeng, W., Ballard, T. E., Tkachenko, A. G., Burns, V.
A., Feldheim, D. L., Melander, C.
Mimicking the Biological Activity of
Diazobenzo[b]fluorene Natural Products with
Electronically Tuned Diazofluorene Analogs. Bioorganic
and Medicinal Chemistry Letters,
2006, 16, (19), 5148-5151.
1. Zeng, W., Ballard, T. E., Melander, C.
Tuning the Oxidation Properties of Vanadium (V) Through
Ligand Stoichiometry. Tetrahedron Letters
2006, 47, (33), 5923-5926.
Review Articles
9. Worthington, R.J. and
Melander, C. Overcoming Resistance to b-Lactam Antibiotics
(Invited). Journal of Organic Chemistry (JOCSynopsis),
Accepted.
8. Blackledge, M.S. and Melander, C. Programmable
DNA-binding Small Molecules (Invited Review).
Bioorganic and Medicinal Chemistry, Accepted.
7. Worthington, R.J., Blackledge, M.S., and Melander, C.
Small Molecule Inhibition of Bacterial Two-Component
Systems to Combat Antibiotic Resistance and Virulence
(Invited Review). Future Medicinal Chemistry,
Accepted.
6. Worthington, R.J. and Melander, C. Combination
Approaches to Combat Multi-Drug Resistant Bacteria (invited
review). Trends in Biotechnology,
2013, 31, (3), 5923-592.
5. Worthington, R.J., Richards, J.J. and Melander,
C. Non-Microbicidal Control of Bacterial
Biofilms with Small Molecules. (invited review)
Anti-Infective Agents, Accepted.
4. Worthington, R.J., Richards, J.J. and Melander, C.
Chemical Control of Bacterial Biofilms. (Invited Review)
Organic and Biomolecular Chemistry,
2012,
10, (37), 7457-7474.
3. Stowe, S.D., Richards, J.J., Tucker, A.T.,
Thompson, R. Melander, C., and Cavanagh, J. Anti-Biofilm
Compounds Derived from Marine Sponges. Marine
Drugs, 2011, 9 (11),
2010-2035.
2. Richards, J.J. and Melander,
C. Small Molecule Approaches Toward the
Non-Microbicidal Modulation of Bacterial Biofilm Growth and
Maintenance. (invited review) Anti-Infective Agents in
Medicinal Chemistry, 2009,
8, 295-314.
1. Richards, J.J. and Melander, C.
Controlling Bacterial Biofilms. (Invited review)
ChemBioChem, 2009, 10
(14), 2287-2294.
Highlights/Commentary
2. Melander, C. and
Margolis, D.M., Forcing an Enemy into the Open. Nature
Chemistry, 2012, 9,
4, 692-693.
1. Worthington, R.J. and Melander, C.
Deconvoluting Interspecies Bacterial Communication.
Angewandte Chemie, 2012,
51 (26), 6314-6315.
Publications prior to
NCSU
19. Burnet, R., Melander,
C., Puckett, J. W., Son, L. S., Wells, R. D., Dervan, P.
B., and Gottesfeld, J. G. DNA sequence-specific polyamides
alleviate transcriptional inhibition associated with long
GAA.TTC repeats in Friedreich’s ataxia. Proceedings of
the National Academy of Science 2006,
103 (91), 11497-11502.
18. Gearha, M. D., Dickinson, L., Ehley, J., Melander, C.,
Dervan, P. B., Wright, P. E., Gottesfeld, J. M. Inhibition
of DNA Binding by Human Estrogen-Related Receptor 2 and
Estrogen Receptor a with Minor Groove Binding Polyamides.
Biochemistry 2005, 44
(11): 4196-4203.
17. Ylisastigui, L., Coull, J. J., Rucker, V. C.,
Melander, C., Bosch, R. J., Brodie, S. J.,
Corey, L., Sodora, D. L., Dervan, P. B., Margolis, D. M.
Polyamides Reveal a Role for Repression in Latency within
Resting T Cells of HIV-Infected Donors. Journal of
Infectious Diseases 2004,
190, (8), 1429-1437.
16. Melander, C., Burnett, R., Gottesfeld, J. M. Regulation
of Gene Expression with Pyrrole-Imidazole Polyamides.
Journal of Biotechnology 2004,
112, (1-2), 195-220.
15. Dickinson, L. A., Burnett, R.,
Melander, C., Edelson, B. S., Arora, P. S., Dervan, P. B.,
Gottesfeld, J. M. Arresting Cancer Proliferation by
Small-Molecule Gene Regulation. Chemistry &
Biology 2004, 11, (11),
1583-1594.
14. Suto, R. K., Edayathumangalam, R. S., White, C.,
Melander, C., Gottesfeld, J. M., Dervan, P. B., Luger, K.
Crystal Structures of Nucleosome Core Particles in Complex
with Minor Groove DNA-Binding Ligands. Journal of
Molecular Biology 2003, 326,
(2), 371-380.
13. Rucker, V. C., Melander, C., Dervan, P. B. Influence of
beta-Alanine on Hairpin Polyamide Orientation in the DNA
Minor Groove. Helvetica Chimica Acta
2003, 86, (6), 1839-1851.
12. Rucker, V. C., Foister, S., Melander, C., Dervan, P. B.
Sequence Specific Fluorescence Detection of Double Strand
DNA. Journal of The American Chemical Society
2003, 125, (5), 1195-1202.
11. Dudouet, B., Burnett, R.,
Dickinson, L. A., Wood, M. R., Melander, C., Belitsky, J.
M., Edelson, B., Wurtz, N., Briehn, C., Dervan, P. B.,
Gottesfeld, J. M. Accessibility of Nuclear Chromatin by DNA
Binding Polyamides. Chemistry & Biology
2003, 10, (9), 859-867.
10. Gottesfeld, J. M., Belitsky, J. M., Melander,
C., Dervan, P. B., Luger, K. Blocking
Transcription Through a Nucleosome with Synthetic DNA
Ligands. Journal of Molecular Biology
2002, 321, (2), 249-263.
9. Ehley, J. A., Melander,
C., Herman, D., Baird, E. E., Ferguson, H. A.,
Goodrich, J. A., Dervan, P. B., Gottesfeld, J. M. Promoter
Scanning for Transcription Inhibition with DNA-Binding
Polyamides. Molecular and Cellular Biology
2002, 22, (6), 1723-1733.
8. Coull, J. J., He, G. C.,
Melander, C., Rucker, V. C., Dervan, P. B., Margolis, D. M.
Targeted Derepression of the Human Immunodeficiency Virus
Type 1 Long Terminal Repeat by Pyrrole-Imidazole
Polyamides. Journal of Virology
2002, 76, (23), 12349-12354.
7. Gottesfeld, J. M., Melander, C.,
Suto, R., Raviol, H., Luger, K., Dervan, P. B.
Sequence-Specific Recognition of DNA in the Nucleosome by
Pyrrole-Imidazole Polyamides. Journal of Molecular
Biology 2001, 309, (3),
615-629
6. Baliga, R., Baird, E. E., Herman, D. M., Melander, C.,
Dervan, P. B., Crothers, D. M. Kinetic Consequences of
Covalent Linkage of DNA Binding Polyamides.
Biochemistry 2001, 40,
(1), 3-8.
5. Melander, C., Herman, D. M., Dervan, P. B.
Discrimination of A/T Sequences in the Minor Groove of DNA
within a Cyclic Polyamide Motif. Chemistry-A European
Journal 2000, 6, (24),
4487-4497.
4. Melander, C., Horne, D. A. Mutarotation of
Tetramethylglucose Catalyzed by Ribonucleosides.
Tetrahedron Letters 1997,
38, (5), 713-716.
3. Melander, C., Horne, D. A. Kinetic Analysis of Ester
Aminolysis Catalyzed by Nucleosides in a Nonpolar Medium.
Evidence of Bifunctional Catalysis. Journal of Organic
Chemistry 1997, 62, (26),
9295-9297.
2. Melander, C., Horne, D. A. Ester Aminolysis Catalyzed by
Nucleosides in a Nonpolar Medium. Journal of Organic
Chemistry 1996, 61, (23),
8344-8346.
1. Kurth, M. J., Randall, L. A. A., Chen, C. X., Melander,
C., Miller, R. B., Mcalister, K., Reitz, G., Kang, R.,
Nakatsu, T., Green, C. Library-Based Lead Compound
Discovery-Antioxidants by an Analogous Synthesis
Deconvolutive Assay Strategy. Journal of Organic
Chemistry 1994, 59, (20),
5862-5864.