The PlanchartLab

 

 

Carson Lunsford, an undergraduate in the Mattingly and Planchart labs, won an Outstanding Poster Award at the 24th Annual NCSU Undergraduate Research Symposium held on April 14.

 

 

 

 

Proteomics. 2015 Apr 21. doi: 10.1002/pmic.201400606.[Epub ahead of print]

 

Machine learning reveals sex-specific 17β-estradiol-responsive expression patterns in white perch (Morone americana) plasma proteins.

 

Schilling J, Nepomuceno AI, Planchart A, Yoder JA, Kelly RM, Muddiman DC, Daniels HV, Hiramatsu N, Reading BJ.

 

PMID: 25900664

 

 

Curr Environ Health Rep. 2014 Sep 7;1(4):341-352.

 

Zebrafish: A marvel of high-throughput biology for 21st century toxicology.

 

Bugel SM, Tanguay RL, Planchart A.

 

PMID: 25678986

 

The Kullman, Mattingly, Planchart and Yoder labs got together over St. Patrick's Day weekend for some fun! Pictures are here!

 

 

 

21 February 2014

 

Elizabeth Cook joined the Planchart and Mattingly labs for her PhD dissertation research. Elizabeth is in the Comparative Biomedical Sciences program of the NCSU College of Veterinary Medicine. Elizabeth is a Raleigh native and received her B.Sc. in Biology from Meredith College in 2012. When Elizabeth is not in the lab, she can be found reading, hanging out in coffee shops, or spending quality time with her two kittens and thinking about soccer.

 

 

 

8 January 2014

 

North Carolina State University's Center for Human Health and the Environment has awarded the Planchart lab a grant to study the effects of inorganic arsenic exposure on innate immunity in zebrafish. The work is a highly interdisciplinary collaboration between the Planchart-Mattingly group and the laboratories of Dr. David Reif and Dr. Jeff Yoder. For more information on this project, see abstract.

 

 

 

 

6 January 2014

 

Taylor DeMorat and Natalie Nielsen have joined the Planchart lab. Taylor's project aims to characterize the effect of exposure to environmental contaminants on the survival of dopaminergic neurons while Natalie's project will look at the role of p53 regulation in the biology of neural crest cells. Welcome to the lab, Taylor and Natalie!

 

 

 

 

Members of the Planchart and Mattingly labs are heading to Phoenix in March 2014 to attend the Society of Toxicology meeting. They will present two papers describing current work. Check back to read abstracts as soon as the society publishes them!

 

 

 

 

 

The Comparative Toxicogenomics Database (CTD), of which Carolyn Mattingly is the PI, was recently featured in a story by WUNC. For more information and to hear the story, click here!

 

 

 

 

Biochem Biophys Res Commun. 2013 Nov 1;440(4):640-5. doi: 10.1016/j.bbrc.2013.09.115. Epub 2013 Oct 5.

 

Analysis of an intronic promoter within Synj2.

 

Planchart A.

 

Department of Biological Sciences, North Carolina State University, Campus Box 7617, Raleigh, NC 27695, USA. Electronic address: ajplanch@ncsu.edu.

 

Abstract

 

Synj2 (synaptojanin 2) encodes an inositol polyphosphate phosphatase that functions in recycling neurotransmitter vesicles and is implicated in spermatogenesis. Transcription of Synj2 is thought to occur from one of two promoters based on analysis of a variable 5' untranslated region. Clustering all known mouse Synj2 transcripts led us to uncover a novel subset of transcripts that appears to derive from a region located within intron 7. We identified two alternate splice variants emanating from use of this promoter. These alternate splice variants manifest developmental stage specificity and somatic versus gametic differences in expression.

 

PMID:
24103750

 

 

Stefanie Denning joined the lab in 2013 and plans to do her Master's thesis research on the topic of binding preferences for the zebrafish transcription factor, foxq1b. Stefanie is a recent graduate of the MCD program at NCSU.

 

 

Lindsey St. Mary will be joining the lab in 2014 and plans to do her PhD dissertation research on the role of inorganic arsenic exposure in eliciting innate immune deficiencies. She will be using several transgenic zebrafish that express detectable markers in subsets of white blood cells important in the defense against pathogens. Lindsey graduated from Oregon State University with a B.Sc. in biology, and did her undergraduate research in the lab of Dr. Robert Tanguay. Lindsey will be co-mentored by Drs. Mattingly and Planchart.