Welcome to the Planchart Lab!
We are located in the Toxicology building on the Centennial Campus of North Carolina State University
Research in the Planchart lab combines high throughput techniques, including proteomics and transcriptomics, to understand how environmental factors affect vertebrate embryonic development. We are focused on identifying genetic modifiers of craniofacial development that can be modulated by changes in the environment during embryogenesis. Specifically, we are interested in discovering regulatory genes that confer phenotypic plasticity, which buffer an organism from changes in its environment that could drastically alter its developmental program if left unchecked. For more information, click the Research link above.
Our model organism is the zebrafish (Danio rerio). You might know it as the Zebra Danio, a small aquarium fish that is easy to keep at home and lives for 1 to 2 years, or more. The advantages of using zebrafish in biomedical research include:
Evolutionary conservation: Zebrafish, like humans, are vertebrates. We shared a common ancenstor with zebrafish approximately 450 million years ago, compared to 800 million years with round worms (C. elegans) and fruit flies (D. melanogaster);
Their genome is sequenced, which allows us to compare our genome with theirs in an attempt to identify conserved regulatory regions;
Females release hundreds of eggs per spawning event, which are externally fertilized and easy to collect;
Zebrafish embryos are transparent, which allows us to view in real-time things like cell movements, organ development, growth, etc.
Post-doctoral fellows interested in our research are encouraged to contact Dr. Planchart directly. Post-baccalaureate students interested in obtaining a Masters or Ph.D. are encouraged to apply directly to one of the following programs: Genetics, Toxicology, Zoology, or Comparative Biomedical Sciences.
Department of Biological Sciences
North Carolina State University
Campus Box 7633
Raleigh, NC 27695-7633
Member: Center for Human Health and the Environment
Member: W.M. Keck Center for Behavioral Biology