Deiters Lab
NC State University
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The Deiters Lab of Chemical Biology
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[79] Stabilization and Photochemical Regulation of Antisense Agents through PEGylation
Govan, J. M.; McIver, A. L.; Deiters, A. Bioconjugate Chem. 2011, 22, 2136-2142.
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[81] A Photoactivatable Small Molecule Inhibitor for Light-Controlled Spatiotemporal Regulation of Rho Kinase in Live Embryos
Morckel, A. R.; Lusic, H.; Farzana, L.; Dush, M. K.; Yoder, J. A.; Deiters, A.; Nascone-Yoder, N. M. Development 2012, 139, 437-442.
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[82] Genetically Encoded Norbornene Directs Site-Specific Cellular Protein Labeling via a Rapid Bioorthogonal Reaction
Lang, K.; Davis, L.; Torres-Kolbus, J.; Chou, C., Deiters, A.; Chin, J. Nature Chemistry 2012, 298-304.
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[83] DNA Computation: A Photochemically Controlled AND Gate
Prokup, A.; Hemphill, J.; Deiters, A. J. Am. Chem. Soc. 2012, 134, 3810-3815.
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[68] Genetically Encoding an Aliphatic Diazirine for Protein Photocrosslinking
Chungjung, C.; Uprety, R.; Davis, L.; Chin, J. W.; Deiters, A. Chem. Sci. 2011, 480-483. PDF
[69] The Human Mitochondrial tRNAMet: Structure/Function Relationship of a Unique Modification in the Decoding of Unconventional Codons
Bilbille, Y.; Gustilo, E. M.; Harris, K. A.; Jones, C. N.; Lusic, H.; Kaiser, R. J.; Delaney, M. O.; Spremulli, L. L.; Deiters, A.; Agris, P. F. J. Mol. Biol. 2011, 406, 257-274. PDF
[72] Heterotaxin: a TGF-b Signaling Inhibitor Identified in a Screen for Left-Right Asymmetric Organ Defects in Xenopus Embryos
Dush, M.; McIver, A. L.; Parr, M.; Young, D. D.; Fisher, J.; Hauck, M. L.;
Deiters, A.; Nascone-Yoder, N. M. Chem. Biol. 2011, 18, 252-253.
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[70] Light-Regulation of Protein Dimerization and Kinase Activity in Living Cells Using Photocaged Rapamycin and Engineered FKBP
Karginov, A. V.; Zou, Y.; Shirvanyants, D.; Kota, P.; Dokholyan, N. V.; Young, D. D.; Hahn, K. M.; Deiters A. J. Am. Chem. Soc. 2011, 133, 420-423. PDF
[71] Light-Activated Kinases Enable Temporal Dissection of Signaling Networks in Living Cells
Gautier, A.; Deiters A.; Chin, J.W.  J. Am. Chem. Soc. 2011, 133, 2124-2127. PDF
[75] Efficacy of C-N Coupling Reactions with a New Multinuclear Copper Complex Catalyst and Its Dissociation into Mononuclear Species
Zou, Y.; Lin, H.; Maggard, P. A.; Deiters, A. Eur. J. Org. Chem. 2011, 4154-4159.
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[74] Light-Activated Gene Editing with a Photocaged Zinc-Finger Nuclease
Chou, C.; Deiters, A. Angew. Chem. Int. Ed. 2011, 50, 6839-6842.
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[78] Photochemical Control of DNA Decoy Function Enables Precise Regulation of
NF-kB Activity
Govan, J. M.; Lively, M. O.; Deiters, A. J. Am. Chem. Soc. 2011, 133, 13176-13182.
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[77] Synthesis of the Pyridine Core of Cyclothiazomycin
Zou, Y.; Liu, Q.; Deiters, A. Org. Lett. 2011, 13, 4352-4355.
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[76] Photochemical Control of Bacterial Signal Processing using a Light-Activated Erythromycin
Gardner, L.; Zou, Y.; Mara, A.; Cropp, T.A.; Deiters, A. Mol. Biosys. 2011, 7, 2554-2557.
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[73] The Human Mitochondrial tRNA(Met): Structure/Function Relationship of a Unique Modification in the Decoding of Unconventional Codons
Bilbille, Y.; Gustilo, E. M.; Harris, K. A.; Jones, C. N.; Lusic, H.; Kaiser, R. J.; Delano, M. O.; Spremulli, L. L.; Deiters, A.; Agris, P. F. J. Mol. Biol. 2011, 406, 257-274.
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[16] A Genetically Encoded, Fluorescent Amino Acid
Summerer, D.; Chen, S.; Wu, N.; Deiters, A.; Chin, J. W.; Schultz, P. G., Proc. Acad. Sci. U.S.A. 2006, 103, 9785-9789.
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[15] General Strategy for the Syntheses of Corynanthe, Tacaman, and Oxindole Alkaloids
Deiters, A.; Petterson, M.; Martin, S. F. J. Org. Chem. 2006, 71, 6547-6561.
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[14] In Vivo Incorporation of an Alkyne into Proteins in E. coli
Deiters, A.; Schultz, P. G. Bioorg. Med. Chem. Lett. 2005, 15, 1521-1524.
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[13] Site-specific In Vivo Labeling of Proteins for NMR Studies
Deiters, A.; Geierstanger, B.; Schultz, P. G. ChemBioChem 2005, 6, 55-58.
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[12] A Genetically Encoded Photocaged Amino Acid
Wu, N.; Deiters, A.; Cropp, A.; King, D.; Schultz, P. G. J. Am. Chem. Soc. 2004, 126, 14306-14307.
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[11] Site-Specific PEGylation of Proteins Containing Unnatural Amino Acids
Deiters, A.; Cropp, T. A.; Summerer, D..; Mukherji, M.; Schultz, P. G. Bioorg. Med. Chem. Lett. 2004, 14, 5743-5745.
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[10] Synthesis of Oxygen- and Nitrogen-Containing Heterocycles by Ring-Closing Metathesis
Deiters, A.; Martin, S. F. Chem. Rev. 2004, 104, 2199-2238.
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[9] Adding Amino Acids with Novel Reactivity to the Genetic Code of Saccharomyces Cerevisiae
Deiters, A.; Cropp, T. A.; Mukherji, M.; Chin, J. W.; Anderson, J. C.; Schultz, P. G. J. Am. Chem. Soc. 2003, 125, 11782-11783.
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[8] Biomimetic Synthesis of the Sarpagan Skeleton - Total Synthesis of the Indole Alkaloids (+)-Geissoschizine and (+)-N-Methylvellosimine
Deiters, A.; Chen, K.; Eary, T.; Martin, S. F. J. Am. Chem. Soc. 2003, 125, 4541-4550.
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[7] Stereoselective Total Synthesis of Dihydrocorynantheol
Deiters, A.; Martin, S. F. Org. Lett. 2002, 4, 3243-3245.
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[6] Planar-Chiral (2E,7Z)- and (2Z,7E)-Cyclonona-2,7-dien-1-yl Carbamates by Asymmetric, Bis-Allylic a,a'-Cycloalkylation - Studies on Their Conformational Stability
Deiters, A.; Mück-Lichtenfeld, C.; Fröhlich, R.; Hoppe, D. Chem. Eur. J. 2002, 8, 1833-1842.
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[5] Asymmetric Synthesis of cis-1,2-Dialkenyl-Substituted Cyclopentanes via (-)-Sparteine-Mediated Lithiation and Cycloalkylation of a 9-Chloro-2,7-nonadienyl Carbamate
Deiters, A.; Hoppe, D. J. Org. Chem. 2001, 66, 2842-2849.
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[4] Enantio- and Diastereoselective Synthesis of a 3,4-Divinylpyrrolidine via Asymmetric Deprotonation and Cyclization of a 9-Chloro-5-aza-2,7-nonadiene
Deiters, A.; Wibbeling, B.; Hoppe, D. Adv. Synth. Catal. 2001, 1, 181-183.
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[3] Enantioselective Synthesis of Functionalized 1,5-Cyclononadienes by Intramolecular Cycloalkylation by Means of a Diallylcoupling
Deiters, A.; Fröhlich, R.; Hoppe, D. Angew. Chem. Int. Ed. Engl. 2000, 39, 2105-2107.
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[2] Asymmetric Synthesis of a (2Z,7E)-Cyclononadiene by an Intramolecular Cycloalkylation and Insight to Its Conformational Properties
Deiters, A.; Mück-Lichtenfeld, C.; Fröhlich, R.; Hoppe, D. Org. Lett. 2000, 2, 2415-2418.
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[1] Chiral Induction by Elimination-Coupled Lithium-Ene Reaction: Synthesis of (+)-(3R,4R)-1,2-Dihydromultifidene
Deiters, A.; Hoppe, D. Angew. Chem. Int. Ed. Engl. 1999, 38, 546-548.
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Patents

Site-Specific Labeling of Proteins for NMR Studies
Deiters, A.; Geierstanger, B.; Schultz, P. G., Prov. U.S. Pat. Appl. 60/645,926, 2005.

In Vivo Incorporation of Alkynyl Amino Acids into Proteins in Eubacteria
Deiters, A.; Schultz, P. G. Prov. U.S. Pat. Appl. 60/634,151, 2004.

Adding Photoregulated Amino Acids to the Genetic Code
Wu, N.; Deiters, A.; Cropp, T. A.; King, D.; Schultz, P. G. Prov. U.S. Pat. Appl. 60/620,625, 2004.

Unnatural Reactive Amino Acid Genetic Code Additions
Deiters, A.; Cropp, T. A.; Chin, J. W.; Anderson, J. C.; Schultz, P. G. U.S. Pat. Appl. 10/826,919, 2004.

Unnatural Reactive Amino Acid Genetic Code Additions
Deiters, A.; Cropp, T. A.; Chin, J. W.; Anderson, J. C.; Schultz, P. G. Int. Pat. Appl. PCT/US2004/011833, 2004.

[18] Pyridines via Solid-Supported [2+2+2] Cycloadditions
Senaiar, R. S.; Young, D. D.; Deiters, A. Chem. Commun. 2006, 1313-1315.
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[19] Photochemical Activation of a Hammerhead Ribozyme
Young, D. D.; Deiters, A. Bioorg. Med. Chem. Lett. 2006, 2658-2661.
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[20] Solid-Supported [2+2+2] Cycloadditions
Young, D. D.; Senaiar, R. S.; Deiters, A. Chem. Eur. J. 2006, 12, 5563-5568.
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[21] A New Photocaging Group for Aromatic N-Heterocycles
Lusic, H.; Deiters, A. Synthesis 2006, 8, 2147-2150.
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[22] Conditional Transgenic and Gene Targeting Methodologies in Zebrafish
Deiters, A.; Yoder, J. Zebrafish 2006, 3, 415-429.
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[23] Photochemical Control of Biological Processes
Young, D. D., Deiters, A. Org. Biomol. Chem. 2007, 5, 999-1005.
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[26] Photochemical DNA Activation
Lusic, H.; Young, D. D.; Lively, M. O.; Deiters, A. Org. Lett. 2007, 9, 1903-1906.
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[24] Photochemical Activation of Protein Expression in Bacterial Cells
Young, D. D. , Deiters, A. Angew. Chem. Int Ed. 2007, 46, 4290-4292.
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[25] A General Approach to Chemo- and Regioselective Cyclotrimerization Reactions
Young, D. D., Deiters, A. Angew. Chem. Int Ed. 2007, 46, 5187-5190.
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[17] A Genetically Encoded Photocaged Tyrosine
Deiters, A.; Groff, D.; Xie, J.; Schultz, P. G.
Angew. Chem. Int. Ed. 2006, 45, 2728-2731. PDF
[27] Microwave-Assisted Solid-Supported Alkyne Cyclotrimerization Reactions for Combinatorial Chemistry
Young, D. D., Sripada, L., Deiters, A. J. Comb. Chem. 2007, 9, 735-738.
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[28] Synthesis of Indanones via Solid-Supported [2+2+2] Cyclotrimerization
Senaiar, R. S.; Teske, J. A.; Young, D. D.; Deiters, A. J. Org. Chem. 2007, 72, 7801-7804.
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[31] Microwave-mediated Nickel-catalyzed Cyclotrimerization Reactions: Total Synthesis of Illudinine
Teske, J. A.; Deiters, A. J. Org. Chem. 2008, 73, 342-345.
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[29] Light-Triggered Polymerase Chain Reaction
Young, D. D.; Edwards, W. F.; Lusic, H.; Lively, M. O.; Deiters, A. Chem. Commun. 2008, 462-464.
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[30] Phenanthridine Synthesis via [2+2+2] Cyclotrimerization Reactions
Sripada, L.; Teske, J. A.; Deiters, A. Org. Biomol. Chem. 2008, 6, 263-265.
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[32] Light-Regulated RNA-Small Molecule Interactions
Young, D. D.; Deiters, A. ChemBioChem 2008, 9, 1225-1228.
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[33] Light-Activated Deoxyguanosine: Photochemical Regulation of Peroxidase Activity
Lusic, H.; Lively, M. O.; Deiters, A. Mol. BioSyst. 2008, 4, 508-511.
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[34] A Cyclotrimerization Route to Cannabinoids
Teske, J. A.; Deiters, A. Org. Lett. 2008, 4, 2195-2198.
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[35] Microwave Activation of Enzymatic Catalysis
Young, D. D.; Nichols, J.; Kelly, R. M.; Deiters, A. J. Am. Chem. Soc. 2008, 130, 10048-10049.
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[36] Small Molecule Inhibitors of MicroRNA miR-21
Gumireddy, K.; Young, D. D.; Xiong, X.; Hogenesch, J. B.; Huang, Q.; Deiters, A. Angew. Chem. Int. Ed. 2008, 47, 7482-7484.
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[37] A General Approach to Triphenylenes and Azatriphenylenes: Total Synthesis of Dehydrotylophorine and Tylophorine
McIver, A.; Young, D. D.; Deiters, A. Chem. Commun. 2008, 4750-4752.
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[41] Synthesis and investigation of the 5-formylcytidine modified, anticodon stem and loop of the human mitochondrial tRNA
Lusic, H.; Estella M. Gustilo, Vendeix, F.; Kaiser, R.; Delaney, M. O.; Graham, W. D.; Moye, V. A.; Cantara, W. A.; Agris, P. F.; Deiters, A. Nucl. Acids Res. 2008, 36, 6548-6557.
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[39] Synthesis of Anthracene and Azaanthracene Fluorophores via [2+2+2] Cyclotrimerization Reactions
Zou, Y.; Young, D. D.; Cruz, A.; Deiters, A. Org. Lett. 2008, 10, 4661-4664.
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[40] Gene Silencing in Mammalian Cells with Light-Activated Antisense Agents
Young, D. D.; Lusic, H.; Lively, M. O.; Yoder, J. A.; Deiters, A. ChemBioChem 2008, 9, 2937-2940.
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[38] Microwave-Assisted Synthesis of Unnatural Amino Acids
Young, D. D.; Torres-Kolbus, J.; Deiters, A. Bioorg. Med. Chem. Lett. 2008, 5478-5480.
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[42] Light Activation of Gene Function in Mammalian Cells via Ribozymes
Young, D. D.; Garner, R. A.; Yoder, J. A.; Deiters, A. Chem. Commun. 2009, 568-570.
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[44] Restriction Enzyme-Free Mutagenesis via the Light Regulation of DNA Polymerization
Young, D. D.; Lusic, H.; Lively, M. O.; Deiters, A. Nucl. Acids Res. 2009, e58.
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[43] Photochemical Regulation of Restriction Endonuclease Activity
Young, D. D.; Govan, J. M.; Lively, M. O.; Deiters, A. ChemBioChem 2009, 10, 1612-1616.
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[46] Light-Activated Cre Recombinase as a Tool for the Spatial and Temporal Control of Gene Function in Mammalian Cells
Edwards, W. F.; Young, D. D.; Deiters, A. ACS Chem. Biol. 2009, 4, 441-445.
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[45] The Effect of Microwave Irradiation on DNA Hybridization
Edwards, W. F.; Young, D. D.; Deiters, A. Org. Biomol. Chem. 2009, 7, 2506-2508.
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[48] Genetic encoding and labeling of aliphatic azides and alkynes in recombinant  proteins via a pyrrolysyl-tRNA synthetase tRNA pair and click chemistry
Nguyen, D.; Lusic, H.; Neumann, H.; Kapadnis, P.; Deiters, A.; Chin, J. J. Am. Chem. Soc. 2009, 131, 8720-8721.
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[49] A Light-Activated DNA Polymerase
Chou, C.; Young, D. D.; Deiters, A. Angew. Chem. Int. Ed. 2009, 121, 6064-6067.
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[47] Development of a Robust and High Throughput Method for Profiling N-linked Glycans Derived from Plasma Glycoproteins by Nano LC FT-ICR Mass Spectrometry
Bereman, M. S.; Young, D. D.; Deiters, A.; Muddiman, D. C. J. Proteome Res. 2009, 8, 3764-3770.
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[50] Open-Vessel Microwave-Mediated [2+2+2] Cyclotrimerization Reactions
Young, D. D.; Teske, J. A.; Deiters, A. Synthesis 2009, 22, 3785-3790.
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[51] Light Activation as a Method of Regulating and Studying Gene Expression
Deiters, A. Curr. Opin. Chem. Biol. 2009, 13, 678-686.
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[53] Principles and Applications of the Photochemical Control of Cellular Processes
Deiters, A. ChemBioChem 2010, 11, 47-53
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[52] Small Molecule Modifiers of the MicroRNA and RNA Interference Pathway
Deiters, A. AAPS J. 2009, 51-60
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[54] Reversible Light-Switching of Cell Signalling by Genetically Encoded Protein Dimerization
Georgianna, W. E.; Deiters, A. ChemBioChem 2010, 11, 301-303. Highlight.
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[55] Generating Permissive Site-specific Unnatural Aminoacyl-tRNA Synthetases
Miyake-Stoner, S. J.; Refakis, C. A.; Hammill, J.T.; Lusic, H.; Hazen, J. L.; Deiters, A.; Mehl, R. A. Biochemistry 2010, 49, 1667-1677.
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[56] Improved Synthesis of the Two-Photon Caging Group 3-Nitro-2-ethyldibenzofuran and its Application to a Caged Thymidine Phosphoramidite
Lusic, H.; Uprety, R.; Deiters, A. Org. Lett. 2010, 12, 916-919.
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[57] Site-specific Incorporation of Fluorotyrosines into Proteins in E. coli by Photochemical Disguise
Wilkins, B. J.; Marionni, S.; Young, D. D.; Liu, J.; Wang, Y.; Di Salvo, M. L.; Deiters, A.; Cropp, T. A. Biochemistry 2010, 49, 1557-1559.
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[58] Photocaged T7 RNA Polymerase for the Light-Activation of Transcription and Gene Function in Pro- and Eukaryotic Cells
Chou, C.; Young, D. D.; Deiters, A. ChemBioChem 2010, 11, 972-977.
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[59] Tricyclic Alkaloid Core Structures Assembled by a Cyclotrimerization Coupled Intramolecular Nucleophilic Substitution Reaction
McIver, A.; Deiters, A. Org. Lett. 2010, 12, 1288-1291.
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[61] Activation and Deactivation of DNAzyme and Antisense Function with Light for the Photochemical Regulation of Gene Expression in Mammalian Cells
Young, D. D.; Lively, M. O.; Deiters, A. J. Am. Chem. Soc. 2010, 132, 6183-6193.
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[65] Photocleavable Polyethylene Glycol for the Light-Regulation of Protein Function
Georgianna, W. E.; Lusic, H.; McIver, A.; Deiters, A., Bioconjugate Chem. 2010, 21, 1404-1407. PDF
[60] Genetically Encoded Photo-control of Protein Localization in Mammalian Cells
Gautier, A.; Nguyen, D. P.; Lusic, H.; An, W.; Deiters, A.; Chin, J. J. Am. Chem. Soc. 2010, 132, 4086-4088.
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[62] Small Molecule Modifiers of MicroRNA miRNA-122 Function for the Treatment of Hepatitis C Virus Infection and Hepatocellular Carcinoma
Young, D. D.; Connelly, C. M.; Grohmann, C.; Deiters, A. J. Am. Chem. Soc. 2010, 132, 7976-7981.
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[64] Recent Advances in the Photochemical Control of Protein Function
Riggsbee, C. W., Deiters, A. Trends Biotechnol. 2010, 28, 468-475.
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[63] Total Synthesis of Cryptoacetalide
Zou, Y.; Deiters, A. J. Org. Chem. 2010, 75, 5355-5358. PDF
[66] Expanding the Genetic Code of Yeast for Incorporation of Diverse Unnatural Amino Acids via a Pyrrolysyl-tRNA Synthetase/tRNA Pair
Hancock, S.; Uprety, R.; Deiters, A.; Chin, J. W. J. Am. Chem. Soc. 2010, 132, 14819-14824. PDF
[67] Photocaged Morpholino Oligomers for the Light-Regulation of Gene Function in Zebrafish and Xenopus Embryos
Deiters, A.; Garner, R. A.; Lusic, H.; Govan, J.; Dush, M.; Nascone-Yoder, N. M.; Yoder, J. A. J. Am. Chem. Soc. 2010, 132, 15644-15650. PDF
[80] Chemo- and Regioselectivity Enhancement in Solid-Supported Reactions
Young, D. D.; Deiters, A. Solid-Phase Organic Synthesis: Concepts, Strategies, and Applications (eds P. H. Toy and Y. Lam), John Wiley & Sons, Inc., Hoboken, NJ 2011, 171-204.
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[85] Activation and Deactivation of Antisense and RNA Interference Function with Light
Govan, J. M; Deiters, A. From Nucleic Acids Sequences to Molecular Medicine (eds V. A. Erdmann and J. Barciszewski), Springer, Heidelberg 2012, 275-291.
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[87] Regulation of Transcription through Light-Activation and Light-Deactivation of Triplex-Forming Oligonucleotides in Mammalian Cells
Govan, J. M.; Uprety, R.; Hemphill, J.; Lively, M. O.; Deiters, A. ACS Chem. Biol. 2012, 7, in print.
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[88] Photocontrol of Tyrosine Phosphorylation in Mammalian Cells via Genetic Encoding of Photocaged Tyrosine
Arbely, E.; Torres-Kolbus, J.; Deiters, A.; Chin, J. W. J. Am. Chem. Soc. 2012, 134, in print.
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[84] A High-Throughput Luciferase Reporter Assay for Small Molecule Inhibitors of microRNA Function
Connelly, C. M.; Thomas, M.; Deiters, A. J. Biomol. Screen. 2012, 17, 822-828.
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[86] Light-Controlled Synthetic Gene Circuits
Gardner, L.; Deiters, A. Curr. Opin. Chem. Biol. 2012, 16, in print.
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[89] Hydrogen Peroxide Induced Activation of Gene Expression in Mammalian Cells using Boronate Estrone
Govan, J. M.; McIver, A. L.; Riggsbee, C.; Deiters, A. Angew. Chem. Int. Ed. 2012, 51, in print.
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