Deiters Lab
Welcome to the Deiters Lab! We are a group of students and postocs with diverse backgrounds, including synthetic chemistry, nucleic acid chemistry, biochemistry, biomolceular engineering, and chemical engineering. We are developing novel chemical tools to elucidate biological processes in an area broadly defined as Chemical Biology. Our multidisciplinary research program involves cell and molecular biology, protein engineering, nucleotide chemistry, amino acid chemistry, photochemistry, small molecule synthesis, as well as medicinal and organometallic chemistry. Click on the links below to learn more about the ongoing projects in the lab.
NC State University
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We are genetically re-wiring the circuitry of bacterial, yeast, and mammalian cells to obtain new biological functions. One approach we are using extensively is the genetic encoding of synthetic, unnatural amino acids.
[ Materials ]
Our research efforts have been generously supported by the American Chemical Society, the March of Dimes Foundation, the Beckman Foundation, Research Corporation, Accelerate Brain Cancer Cure, the North Carolina Biotechnology Center, the National Science Foundation, the American Cancer Society, the Bill & Melinda Gates Foundation, and the National Institutes of Health.
Synthetic chemistry is the enabling technology for all projects in the lab. We are developing new synthetic methodologies and are applying existing methods to the synthesis of molecules with new chemical and biological function.
The discovery of new small organic molecules that inhibit or activate specific biological pathways is a major research topic in the lab. These compounds have therapeutic implications in cancer and viral infections.
Light is a unique external control element that enables the regulation of biological processes with unprecedented spatial and temporal resolution. Several projects in the lab involve the engineering of light-responsive nucleic acids and proteins, and their application in photochemical genetics.