Alex Nevzorov Group

NC State University, Department of Chemistry

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Pictured above from left to right: Back row: Alex Nevzorov, Wenxing Tang, Robert Knox,
Front row: Yuayuan Yin, Deanna Tesch, Sophie Koroloff, and Erica Vogel.

About Us

Membrane Proteins (MPs) comprise about 30% of the human genome and play major role in signal transduction, ion transport, cell recognition, and energy activation. MPs, such as g-protein coupled receptors (GPCRs), represent about 60% of drug targets aimed at treating a broad spectrum of diseases, including AIDS, cancer, asthma, allergies, stomach ulcers, and pain. However, merely 1% of these important drug targets' structures have been determined by X-ray crystallography and solution NMR methods due to the difficulties in crystallization of MPs and the presence of the lipid molecules required to maintain their native folds. For this reason, the Nevzorov Group uses Oriented Sample Solid State Nuclear Magnetic Resonance (OS-NMR) on Membrane Proteins reconstituted in bicelles for structure determination under native conditions. Performing experiements for structural determination under native conditions will help us to better understand MPs functions and lead to better drug design. The Nevzorov group welcomes undergraduate, graduate,and postdoctoral candidates to take part in the research.

Current Research

News & Upcoming Events

Reasearch in the Nevzorov Group spans several areas of study including Biochemistry, Biophysics, and Solid State Nuclear Magnetic Resonance:

Development of new solid-state NMR methodology for the structural studies of membrane proteins.

Expression, purification, and reconsitution of membrane proteins into Membrane Mimetics for NMR Structural Studies and Detection of Ligand Binding.

Structural fitting algorithms using angular constraints.

Congratulations to Wenxing Tang on passing his final defense in December, 2012, and on his new job as a post doc. with Joanna Long at University of Florida!

We are excited about our new Dynamic Nuclear Polarization (DNP) system which is currently being set up for use!

Graduate recruitment weekend poster session March 22 at the Doubletree downtown Raleigh

ENC Conference April 14-19, 2013 Asilomar Conference Grounds, CA